NDUFV1 Antikörper (N-Term)

Produktnummer ABIN1881573

Produktdetails anti-NDUFV1 Antikörper

Target: NDUFV1 (NADH Dehydrogenase (Ubiquinone) Flavoprotein 1, 51kDa (NDUFV1))

Bindungsspezifität: AA 21-50, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NDUFV1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, Pr, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NDUFV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human NDUFV1.

Klon: RB40529

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-NDUFV1 Antikörper (ABIN1881573)

Morán, Rivera, Sánchez-Aragó, Blázquez, Merinero, Ugalde, Arenas, Cuezva, Martín: "Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts." in: Biochimica et biophysica acta, Vol. 1802, Issue 5, pp. 443-53, (2010) (PubMed).

Saito, Kawamoto, Kamatani: "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects." in: Journal of human genetics, Vol. 54, Issue 6, pp. 317-23, (2009) (PubMed).

Starr, Shiels, Harris, Pattie, Pearce, Relton, Deary: "Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey." in: Mechanisms of ageing and development, Vol. 129, Issue 12, pp. 745-51, (2008) (PubMed).

Details zu NDUFV1

Target: NDUFV1 (NADH Dehydrogenase (Ubiquinone) Flavoprotein 1, 51kDa (NDUFV1))

Andere Bezeichnung: NDUFV1 (NDUFV1 Produkte)

Synonyme: GB17095 antikoerper, uqor1 antikoerper, DDBDRAFT_0188174 antikoerper, DDBDRAFT_0191420 antikoerper, DDB_0188174 antikoerper, DDB_0191420 antikoerper, wu:fc01f01 antikoerper, wu:fc12f12 antikoerper, zgc:86620 antikoerper, CI-51kD antikoerper, CI-51K antikoerper, CI51KD antikoerper, UQOR1 antikoerper, NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial antikoerper, NADH:ubiquinone oxidoreductase core subunit V1 antikoerper, NADH dehydrogenase ubiquinone flavoprotein 1 antikoerper, NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa antikoerper, NADH dehydrogenase (ubiquinone) flavoprotein 1 antikoerper, NADH:ubiquinone oxidoreductase core subunit V1 L homeolog antikoerper, LOC408367 antikoerper, NDUFV1 antikoerper, ndufv1 antikoerper, Ndufv1 antikoerper, LOC100179486 antikoerper, ndufv1.L antikoerper

Hintergrund: The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I, a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction, a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht: 50817

NCBI Accession: NP_001159574, NP_009034

UniProt: P49821