This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This NCBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-675 amino acids from the C-terminal region of human NCBP1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Hwang, Sato, Tang, Matsuda, Maquat: "UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps." in: Molecular cell, Vol. 39, Issue 3, pp. 396-409, (2010) (PubMed).
Kim, Cho, Choi, Kim, Kim, Ko, Jang, Kim: "A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation." in: Genes & development, Vol. 23, Issue 17, pp. 2033-45, (2009) (PubMed).
Dias, Wilson, Rojas, Ambrosio, Cerione: "The molecular basis for the regulation of the cap-binding complex by the importins." in: Nature structural & molecular biology, Vol. 16, Issue 9, pp. 930-7, (2009) (PubMed).
Worch, Jankowska-Anyszka, Niedzwiecka, Stepinski, Mazza, Darzynkiewicz, Cusack, Stolarski: "Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex." in: Journal of molecular biology, Vol. 385, Issue 2, pp. 618-27, (2009) (PubMed).
Ma, Yoon, Richardson, Jülich, Blenis: "SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs." in: Cell, Vol. 133, Issue 2, pp. 303-13, (2008) (PubMed).
Target
NCBP1
(Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))
CBP80 antikoerper, CG7035 antikoerper, Dmel\\CG7035 antikoerper, EG:84H4.3 antikoerper, ncbp antikoerper, sto1 antikoerper, cbp80 antikoerper, AU014645 antikoerper, AW538051 antikoerper, NCBP antikoerper, Sto1 antikoerper, ncbp1 antikoerper, ABA HYPERSENSITIVE 1 antikoerper, ATCBP80 antikoerper, CAP-BINDING PROTEIN 80 antikoerper, ENS antikoerper, ENSALADA antikoerper, NUCLEAR CAP-BINDING PROTEIN CBP80 antikoerper, T10F5.8 antikoerper, T10F5_8 antikoerper, cap binding protein 80 antikoerper, nuclear cap binding protein subunit 1 antikoerper, nuclear cap binding protein subunit 1 S homeolog antikoerper, nuclear cap binding protein subunit 1, 80kDa antikoerper, nuclear cap binding protein subunit 1 L homeolog antikoerper, ARM repeat superfamily protein antikoerper, Nuclear cap-binding protein subunit 1-A antikoerper, Nuclear cap-binding protein subunit 1 antikoerper, Cbp80 antikoerper, ncbp1 antikoerper, ncbp1.S antikoerper, NCBP1 antikoerper, Ncbp1 antikoerper, ncbp1.L antikoerper, ABH1 antikoerper, nbp1a antikoerper, ncbp-1 antikoerper
Hintergrund
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay.