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MBD4 Antikörper (AA 323-351)

MBD4 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB40399 unconjugated
Produktnummer ABIN1881532
  • Target Alle MBD4 Antikörper anzeigen
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Bindungsspezifität
    • 9
    • 9
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 323-351
    Reaktivität
    • 33
    • 5
    • 3
    • 1
    Human
    Wirt
    • 32
    • 1
    • 1
    Kaninchen
    Klonalität
    • 33
    • 1
    Polyklonal
    Konjugat
    • 17
    • 4
    • 4
    • 3
    • 3
    • 3
    Dieser MBD4 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 24
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This MBD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-351 amino acids from the Central region of human MBD4.
    Klon
    RB40399
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Arora, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Thyagarajan: "Polymorphisms in the base excision repair pathway and graft-versus-host disease." in: Leukemia, Vol. 24, Issue 8, pp. 1470-5, (2010) (PubMed).

    Thyagarajan, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Arora: "Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations." in: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Vol. 16, Issue 8, pp. 1084-9, (2010) (PubMed).

    Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

  • Target
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Andere Bezeichnung
    MBD4 (MBD4 Produkte)
    Synonyme
    MED1 antikoerper, Med1 antikoerper, methyl-CpG binding domain 4, DNA glycosylase antikoerper, methyl-CpG binding domain protein 4 antikoerper, methyl-CpG binding domain 4 DNA glycosylase antikoerper, MBD4 antikoerper, Mbd4 antikoerper
    Hintergrund
    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
    Molekulargewicht
    66051
    NCBI Accession
    NP_001263199, NP_001263201, NP_001263202, NP_003916
    UniProt
    O95243
    Pathways
    DNA Reparatur
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