MBD4 Antikörper (Methyl-CpG Binding Domain Protein 4) (AA 323-351)

Details for Product anti-MBD4 Antibody No. ABIN1881532, Anbieter: Anmelden zum Anzeigen
Antigen
  • MED1
  • Med1
  • methyl-CpG binding domain protein 4
  • MBD4
  • Mbd4
Epitop
AA 323-351, Center
27
15
13
11
7
7
2
2
1
1
1
1
Reaktivität
Human
66
11
4
1
Wirt
Kaninchen
66
2
1
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser MBD4 Antikörper ist unkonjugiert
5
5
5
4
4
4
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
48
35
27
14
13
12
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This MBD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-351 amino acids from the Central region of human MBD4.
Klon RB40399
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Andere Bezeichnung MBD4 (MBD4 Antibody Abstract)
Hintergrund DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.

Synonyms: MBD4, MED1, Methyl-CpG-binding domain protein 4, Methyl-CpG-binding endonuclease 1, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase
NCBI Accession NP_001263201, NP_003916, NP_001263202, NP_001263199
UniProt O95243
Forschungsgebiet Chromatin and Nuclear Signaling
Pathways DNA Reparatur
Applikationshinweise WB: 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Bilder des Herstellers
Western Blotting (WB) image for anti-Methyl-CpG Binding Domain Protein 4 (MBD4) (AA 323-351), (Center) antibody (ABIN1881532) MBD4 Antibody (Center) (ABIN1881532) western blot analysis in SK-BR-3 cell line lysat...
Produkt verwendet in: Arora, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Thyagarajan: "Polymorphisms in the base excision repair pathway and graft-versus-host disease." in: Leukemia, Vol. 24, Issue 8, pp. 1470-5, 2010 (PubMed).

Thyagarajan, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Arora: "Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations." in: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Vol. 16, Issue 8, pp. 1084-9, 2010 (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

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