KCNMB2 Antikörper (N-Term)

Produktnummer ABIN1881476

Produktdetails anti-KCNMB2 Antikörper

Target: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNMB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KCNMB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNMB2.

Klon: RB42799

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-KCNMB2 Antikörper (ABIN1881476)

Treviño, Yang, French, Hunger, Carroll, Devidas, Willman, Neale, Downing, Raimondi, Pui, Evans, Relling: "Germline genomic variants associated with childhood acute lymphoblastic leukemia." in: Nature genetics, Vol. 41, Issue 9, pp. 1001-5, (2009) (PubMed).

Lee, Cui: "{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia." in: The Journal of physiology, Vol. 587, Issue Pt 7, pp. 1481-98, (2009) (PubMed).

Zarei, Song, Wilson, Cox, Colom, Knaus, Stefani, Toro: "Endocytic trafficking signals in KCNMB2 regulate surface expression of a large conductance voltage and Ca(2+)-activated K+ channel." in: Neuroscience, Vol. 147, Issue 1, pp. 80-9, (2007) (PubMed).

Zeng, Benzinger, Xia, Lingle: "BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 17, pp. 4707-15, (2007) (PubMed).

Orio, Torres, Rojas, Carvacho, Garcia, Toro, Valverde, Latorre: "Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel." in: The Journal of general physiology, Vol. 127, Issue 2, pp. 191-204, (2006) (PubMed).

Details zu KCNMB2

Target: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Andere Bezeichnung: KCNMB2 (KCNMB2 Produkte)

Synonyme: KCNMB3 antikoerper, zgc:101842 antikoerper, KCNMB2 antikoerper, 2700049B16Rik antikoerper, 3110031N04Rik antikoerper, Kcmb2 antikoerper, potassium calcium-activated channel subfamily M regulatory beta subunit 2 antikoerper, potassium large conductance calcium-activated channel, subfamily M, beta member 2 antikoerper, KCNMB2 antikoerper, kcnmb2 antikoerper, Kcnmb2 antikoerper

Hintergrund: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Two variants encoding the same protein have been found for this gene. [provided by RefSeq].

Molekulargewicht: 27130

NCBI Accession: NP_001265840, NP_005823, NP_852006

UniProt: Q9Y691