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Kv1.4 Antikörper (C-Term)

KCNA4 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB41939 unconjugated
Produktnummer ABIN1881472
  • Target Alle Kv1.4 (KCNA4) Antikörper anzeigen
    Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))
    Bindungsspezifität
    • 15
    • 13
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 591-619, C-Term
    Reaktivität
    • 40
    • 9
    • 7
    • 1
    • 1
    • 1
    Human
    Wirt
    • 41
    • 2
    Kaninchen
    Klonalität
    • 42
    • 1
    Polyklonal
    Konjugat
    • 19
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Kv1.4 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 19
    • 13
    • 13
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    B, M, Rat
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.
    Klon
    RB41939
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product KCNA4 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Schwetz, Norring, Bennett: "N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating." in: Biochimica et biophysica acta, Vol. 1798, Issue 3, pp. 367-75, (2010) (PubMed).

    Lee, Lee, Choi, Yoon, Pyo, Shin, Choi, Lim, Rhim, Won, Lim, Choe, Kim, Kim, Nah: "Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue." in: Molecular pharmacology, Vol. 73, Issue 3, pp. 619-26, (2008) (PubMed).

    Mckeown, Burnham, Hodson, Jones et al.: "Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in..." in: The Journal of biological chemistry, Vol. 283, Issue 44, pp. 30421-32, (2008) (PubMed).

  • Target
    Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))
    Andere Bezeichnung
    KCNA4 (KCNA4 Produkte)
    Synonyme
    KV1.4 antikoerper, KCNA4 antikoerper, Kv1.4 antikoerper, DKFZp459N0126 antikoerper, KCHAN antikoerper, Kv4 antikoerper, RHK1 antikoerper, RK3 antikoerper, HBK4 antikoerper, HK1 antikoerper, HPCN2 antikoerper, HUKII antikoerper, KCNA4L antikoerper, KCNA8 antikoerper, PCN2 antikoerper, potassium voltage-gated channel subfamily A member 4 antikoerper, potassium voltage-gated channel subfamily A member 4 S homeolog antikoerper, potassium voltage-gated channel, shaker-related subfamily, member 4 antikoerper, KCNA4 antikoerper, LOC100622932 antikoerper, kcna4.S antikoerper, Kcna4 antikoerper
    Hintergrund
    Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
    Molekulargewicht
    73257
    NCBI Accession
    NP_002224
    UniProt
    P22459
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