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TIM3 Antikörper (AA 167-194)

TIM 3 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB41963 unconjugated
Produktnummer ABIN1881402
  • Target Alle TIM3 (TIM 3) Antikörper anzeigen
    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
    Bindungsspezifität
    • 19
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 167-194
    Reaktivität
    • 74
    • 39
    • 4
    • 3
    • 2
    • 1
    Human
    Wirt
    • 47
    • 29
    • 29
    • 2
    Kaninchen
    Klonalität
    • 64
    • 42
    • 1
    Polyklonal
    Konjugat
    • 60
    • 9
    • 9
    • 8
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TIM3 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 45
    • 36
    • 25
    • 15
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This HAVCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-194 amino acids from the Central region of human HAVCR2.
    Klon
    RB41963
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product TIM 3 Primärantikörper
  • Applikationshinweise
    WB: 1:2000. WB: 1:2000. WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Cao, Zhu, Zhu, Li, Zhang, Xu, Zhang: "Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer." in: Cancer immunology, immunotherapy : CII, Vol. 59, Issue 12, pp. 1851-7, (2010) (PubMed).

    Dorfman, Hornick, Shahsafaei, Freeman: "The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms." in: Human pathology, Vol. 41, Issue 10, pp. 1486-94, (2010) (PubMed).

    Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

    Dardalhon, Anderson, Karman, Apetoh, Chandwaskar, Lee, Cornejo, Nishi, Yamauchi, Quintana, Sobel, Hirashima, Kuchroo: "Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1383-92, (2010) (PubMed).

    Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, (2010) (PubMed).

  • Target
    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
    Andere Bezeichnung
    HAVCR2 (TIM 3 Produkte)
    Synonyme
    HAVCR2 antikoerper, MGC140131 antikoerper, HAVcr-2 antikoerper, KIM-3 antikoerper, TIM3 antikoerper, TIMD-3 antikoerper, TIMD3 antikoerper, Tim-3 antikoerper, TIM-3 antikoerper, Tim3 antikoerper, Timd3 antikoerper, tim3 antikoerper, hepatitis A virus cellular receptor 2 antikoerper, HAVCR2 antikoerper, Havcr2 antikoerper
    Substanzklasse
    Virus
    Hintergrund
    CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
    Molekulargewicht
    33394
    NCBI Accession
    NP_116171
    UniProt
    Q8TDQ0
    Pathways
    Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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