CSH1 Antikörper (N-Term)

Produktnummer ABIN1881233

Produktdetails anti-CSH1 Antikörper

Target: CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))

Bindungsspezifität: AA 42-70, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CSH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human CSH1.

Klon: RB41664

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CSH1 Antikörper (ABIN1881233)

Markl-Hahn, Neugebauer, Lenke, Ecker, Merz, McCook, Khoder, Brucker, Radermacher, Waller, Clapp, Bertsch, Triebel: "Human Placental Tissue Contains A Placental Lactogen-Derived Vasoinhibin." in: Journal of the Endocrine Society, Vol. 6, Issue 4, pp. bvac029, (2022) (PubMed).

Voorhees, Brooks: "Obligate ordered binding of human lactogenic cytokines." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20022-30, (2010) (PubMed).

Männik, Vaas, Rull, Teesalu, Rebane, Laan: "Differential expression profile of growth hormone/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 5, pp. 2433-42, (2010) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Varvarigou, Liatsis, Vassilakos, Decavalas, Beratis: "Effect of maternal smoking on cord blood estriol, placental lactogen, chorionic gonadotropin, FSH, LH, and cortisol." in: Journal of perinatal medicine, Vol. 37, Issue 4, pp. 364-9, (2009) (PubMed).

Chen, Kibriya, Jasmine, Santella, Senie, Ahsan: "Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk." in: Cancer research, Vol. 68, Issue 23, pp. 9729-34, (2008) (PubMed).

Details zu CSH1

Target: CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))

Andere Bezeichnung: CSH1 (CSH1 Produkte)

Synonyme: CS-1 antikoerper, CSA antikoerper, CSMT antikoerper, PL antikoerper, hCS-A antikoerper, CS-2 antikoerper, CSB antikoerper, hCS-B antikoerper, chorionic somatomammotropin hormone 1 antikoerper, chorionic somatomammotropin hormone 2 antikoerper, CSH1 antikoerper, CSH2 antikoerper

Hintergrund: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq].

NCBI Accession: NP_001308, NP_066271

UniProt: P01243

Pathways: Response to Growth Hormone Stimulus