Programmed Cell Death 1 (PDCD1) Antikörper

Antigen: Programmed Cell Death 1 (PDCD1)

Synonyme: PD1, CD279, SLEB2, hPD-1, hPD-l

Klonalität: Polyklonal

Wirt: Ziege

Reaktivität: Human

Applikation: ELISA, Western Blot (WB)

Produktnummer: ABIN185400

Produktbeschreibung

Weitere Bezeichnung: PDCD1

Gen-ID: 5133

Immunogen: C-GELDFQWREKTPE

Format: Affinity-purified

Beschreibung: All names and symbols: PDCD1 , programmed cell death 1 , HGNC:8760, PD1, SLEB2, hPD-1, hPD-l, programmed death 1. Official Symbol: PDCD1 . RefSeq number(s): NP_005009.1

Spezifität: Human, Mouse, Rat, Dog

Anwendungen

Applikationshinweise: Peptide ELISA: antibody detection limit dilution 1:16,000. Western Blot: Approx 28-30kDa band observed in Human Bone Marrow lysates (calculated MW of 31.7kDa according to NP_005009.1). Recommended concentration: 0.5-1.5µg/ml.

Reinigung: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Buffer: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Lagerung: Aliquot and store at -20°C. Minimize freezing and thawing.

Forschungsgebiet: Krebs

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

ABIN185400 (0.6µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Publikationen

Publikationen: Sanghera, Manzi, Bontempo et al.: "Role of an intronic polymorphism in the PDCD1 gene with the risk of sporadic systemic lupus erythematosus and the occurrence of antiphospholipid antibodies." in: Human genetics, Vol. 115, Issue 5, pp. 393-8, 2004 (PubMed).

Ferreiros-Vidal, Gomez-Reino, Barros et al.: "Association of PDCD1 with susceptibility to systemic lupus erythematosus: evidence of population-specific effects." in: Arthritis and rheumatism, Vol. 50, Issue 8, pp. 2590-7, 2004 (PubMed).

Nielsen, Laustrup, Voss et al.: "A putative regulatory polymorphism in PD-1 is associated with nephropathy in a population-based cohort of systemic lupus erythematosus patients." in: Lupus, Vol. 13, Issue 7, pp. 510-6, 2004 (PubMed).

Sheppard, Fitz, Lee et al.: "PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta." in: FEBS letters, Vol. 574, Issue 1-3, pp. 37-41, 2004 (PubMed).