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EXOSC6 Antikörper (N-Term)

EXOSC6 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN184072
  • Target Alle EXOSC6 Antikörper anzeigen
    EXOSC6 (Exosome Component 6 (EXOSC6))
    Bindungsspezifität
    • 14
    • 12
    N-Term
    Reaktivität
    • 21
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Schwein, Zebrafisch (Danio rerio)
    Wirt
    • 21
    Kaninchen
    Klonalität
    • 21
    Polyklonal
    Konjugat
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser EXOSC6 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 14
    • 2
    • 2
    Western Blotting (WB)
    Sequenz
    LYAADEEEAP GTRDPTRLRP VYARAGLLSQ AKGSAYLEAG GTKVLCAVSG
    Homologie
    Cow: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%
    Produktmerkmale
    This is a rabbit polyclonal antibody against EXOSC6. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human EXOSC6
    Top Product
    Discover our top product EXOSC6 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 272 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    EXOSC6 (Exosome Component 6 (EXOSC6))
    Andere Bezeichnung
    EXOSC6 (EXOSC6 Produkte)
    Synonyme
    exosc6 antikoerper, RAR-gamma antikoerper, id:ibd1130 antikoerper, wu:fe17d05 antikoerper, zgc:110071 antikoerper, EAP4 antikoerper, MTR3 antikoerper, Mtr3p antikoerper, hMtr3p antikoerper, p11 antikoerper, 2610510N21Rik antikoerper, C76919 antikoerper, Mtr3 antikoerper, exosome component 6 antikoerper, EXOSC6 antikoerper, exosc6 antikoerper, CpipJ_CPIJ018071 antikoerper, Exosc6 antikoerper
    Hintergrund
    EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
    Alias Symbols: p11, EAP4, MTR3, Mtr3p, hMtr3p
    Protein Interaction Partner: CEP250, DCP1B, EXOSC6, CHPF, MIF4GD, XRN1, NDUFA13, MRPL4, EXOSC1, MRPS18B, UPF2, RAB3GAP2, SKIV2L2, GSE1, EXOSC7, EXOSC8, ZFP36, TUFM, EXOSC10, MAN2C1, ESRRA, C1QBP, AICDA, DIS3L, EXOSC4, EXOSC3, CUL3, ELAVL1, HDGF, UBC, EXOSC5, DNAJC30, MOCS3, MPP6, EXO
    Protein Size: 272
    Molekulargewicht
    30 kDa
    Gen-ID
    118460
    NCBI Accession
    NM_058219, NP_478126
    UniProt
    Q5RKV6
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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