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PRMT2 Antikörper (N-Term)

PRMT2 Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen, Hund WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN183891
  • Target Alle PRMT2 Antikörper anzeigen
    PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
    Bindungsspezifität
    • 13
    • 9
    • 8
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 59
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Schwein, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen, Hund
    Wirt
    • 53
    • 5
    • 1
    Kaninchen
    Klonalität
    • 55
    • 4
    Polyklonal
    Konjugat
    • 32
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRMT2 Antikörper ist unkonjugiert
    Applikation
    • 51
    • 31
    • 20
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS FLRGEKILIL
    Homologie
    Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against PRMT2. It was validated on Western Blot and immunohistochemistry.
    Aufreinigung
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 433 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Burton, Muller, Tu, Padilla-Longoria, Guccione, Torres-Padilla: "Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo." in: Cell reports, Vol. 5, Issue 3, pp. 687-701, (2013) (PubMed).

    Zhong, Cao, Zu, Hong, Yang, Liu, Xiao, Ding, Zhao, Liu, Wen: "Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma." in: The FEBS journal, Vol. 279, Issue 2, pp. 316-35, (2012) (PubMed).

    Spellman, Ahmed, Dubach, Gardiner: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, (2012) (PubMed).

    Zhong, Cao, Hong, Yang, Zu, Xiao, Liu, Wen: "Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer." in: Gene, Vol. 487, Issue 1, pp. 1-9, (2011) (PubMed).

  • Target
    PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
    Andere Bezeichnung
    PRMT2 (PRMT2 Produkte)
    Synonyme
    PRMT2 antikoerper, DKFZp459N1919 antikoerper, HRMT1L1 antikoerper, Hrmt1l1 antikoerper, AI504737 antikoerper, protein arginine methyltransferase 2 antikoerper, protein arginine methyltransferase 2 L homeolog antikoerper, protein arginine N-methyltransferase 2 antikoerper, PRMT2 antikoerper, Prmt2 antikoerper, prmt2.L antikoerper
    Hintergrund
    The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
    Alias Symbols: HRMT1L1
    Protein Interaction Partner: FIP1L1, SPAG8, RIPK2, BAG6, RB1, HNRNPA1, E2F1, UBC, PSMB3, HHV8GK18_gp81, CPSF7, DMRTB1, HNRNPUL1, PRMT2, THRB, PGR, NCOA6, NCOA1, ESR2, RXRA, PRRC2A, ESR1, PPARG, RARA,
    Protein Size: 433
    Molekulargewicht
    48 kDa
    Gen-ID
    3275
    NCBI Accession
    NM_001535, NP_001526
    UniProt
    P55345
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding
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