ID4 Antikörper (N-Term)
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- Target Alle ID4 Antikörper anzeigen
- ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Schwein, Hund, Zebrafisch (Danio rerio)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ID4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC
- Homologie
- Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 85%
- Produktmerkmale
- This is a rabbit polyclonal antibody against ID4. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human ID4
- Top Product
- Discover our top product ID4 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 161 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability." in: Carcinogenesis, Vol. 32, Issue 4, pp. 636-42, (2011) (PubMed).
: "
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LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability." in: Carcinogenesis, Vol. 32, Issue 4, pp. 636-42, (2011) (PubMed).
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- Target
- ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))
- Andere Bezeichnung
- ID4 (ID4 Produkte)
- Synonyme
- Idb4 antikoerper, bHLHb27 antikoerper, cb547 antikoerper, fb77d04 antikoerper, sb:cb547 antikoerper, wu:fb77d04 antikoerper, zgc:123214 antikoerper, bhlhb27 antikoerper, id4 antikoerper, id4a antikoerper, idb4 antikoerper, IDB4 antikoerper, inhibitor of DNA binding 4 antikoerper, inhibitor of DNA binding 4, HLH protein antikoerper, inhibitor of DNA binding 4, HLH protein S homeolog antikoerper, Id4 antikoerper, id4 antikoerper, id4.S antikoerper, ID4 antikoerper
- Hintergrund
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Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995).[supplied by OMIM].
Alias Symbols: IDB4, bHLHb27
Protein Interaction Partner: TCF3, TCF4, ID3, MYOD1, HES1,
Protein Size: 161 - Molekulargewicht
- 17 kDa
- Gen-ID
- 3400
- NCBI Accession
- NM_001546, NP_001537
- UniProt
- P47928
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