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Amphiregulin (AREG) Antikörper

Antigen

Amphiregulin (AREG)
Synonyme AR, SDGF, CRDGF, MGC13647, Sdgf, AREG, AREGB, MGC152310
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen
Reaktivität
Alternativen

Human, Maus
Applikation
Alternativen Immunpräzipitation (IP)
Produktnummer ABIN181313
Menge 0.5 mg
Preis 390,00 €   Zzgl. Versandkosten €40,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung
Anwendungen Alternativen Sekundärantikörper zurück nach oben

Produktmerkmale Synonyms: CRDGF, AREG, SDGF, Colorectum cell-derived growth factor, Schwannoma-Derived GrowthFactor
Weitere Bezeichnung Amphiregulin
Swiss-Prot P15514
Immunogen A synthetic 19-mer peptide, corresponding to aa 8-26 (VKPPQNKTESENTSDKPKR) from thesecreted amphiregulin of human origin.
Beschreibung Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The maturesecreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator,which is generated by proteolytic processing of a 252-amino acid transmembraneprecursor. Seven different polypeptide ligands, which derive from distinct genes, arecapable of binding to the extracellular domain of EGFR. These ligands include EGF,TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factorscontain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteineresidues that generate 3 loops through the formation of disulfide bonds. AR protein hasbeen localized by immunohistochemistry to the epithelium of the colon, stomach,pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers ofbreast, colon, stomach, and pancreas.
Spezifität Highly specific for Amphiregulin. Cellular Localization: Cytoplasmic and/or nuclear. Mol. Wt. of Antigen: 18. 5-22. 5kDa. Species: Human and Mouse. Others not tested.

Anwendungen
Alternativen Sekundärantikörper zurück nach oben

Applikationshinweise Immunoprecipitation (Native): use Protein A and Ab at 10 g/mg protein lysate. PositiveControl: LS174T cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Buffer 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide
Lagerung Store at 2-8°C for up to one month or in aliquots at -20°C for longer. Avoid repeated freezethaw cycles! Shelf life: one year from despatch.
Forschungsgebiet Krebs, Wachstumsfaktoren
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen Sekundärantikörper zurück nach oben

Alternativen zu Antigen "Amphiregulin (AREG)", Typ "Antikörper" finden
Wirte Kaninchen (27), Maus (2)
Reaktivitäten Human (29), Maus (25), Ratte (Rattus) (20), Rind (Kuh) (17), Pferd (17), Hund (16), Kaninchen (16), Schaf (16), Schwein (3)
Applikationen Durchflusszytometrie (FACS) (18), Immunfluoreszenz (IF) (18), Western Blot (WB) (7), Immunpräzipitation (IP) (6), Immunhistochemie (Paraffinschnitte) (IHC (p)) (5), ELISA (3), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), ELISA (Detektionsantikörper) (1), Enzyme Immunoassay (EIA) (1), Immunoelectron Microscopy (IEM) (1)
Konjugate Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitope AA 8-26 (1)