Podoplanin (PDPN) Antikörper

Antigen: Podoplanin (PDPN)

Synonyme: T1A, GP36, GP40, Gp38, OTS8, T1A-2, AGGRUS, HT1A-1, PA2.26, T1a, OTS-8, T1alpha, RANDAM-2, E11, RTI40, T1-alpha, PDPN

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN180259

Produktbeschreibung

Weitere Bezeichnung: Podoplanin

Immunogen: Synthetic peptide of the part of Human Podoplanin Purification: Purified with antigen peptide

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Podoplanin belongs to a type-I transmembrane protein which is a sialoglycoprotein with some O-glycosylation sites. It is known as a lymphatic endothelium-specific marker and believed to have a platelet-aggregating activity and to promote hematogenous metastasis of cancer cells. Podoplanin is thought to be expressed on the shape alteration of squamous cells and to relate to transition of cytoskeletal actin structure. Also, its activity which decreases the adhesion ability of cells and promotes their metastasis has drawn researchers' attention. Additionally, podoplanin is reported to be expressed in human tumors such as brain tumor, oral cavity cancer, head and neck cancer, esophageal cancer, lung cancer, testicular tumor, cervical cancer and malignant mesothelioma.

Anwendungen

Applikationshinweise: This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is about 1 g/mL, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration about 5 ug /mL.

Reinigung: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 Reconstitution: 1.0 mL deionized water will be added to the product (the conc. comes up 100 ug /mL)

Lagerung: Lyophilized product, 5 years at 2 - 8 °C

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

malignant pleural mesothelioma

vessels, lymphatic vessels

anti-Podoplanin (PDPN) antibody (Image 3)