Alpha2, 6-Sialyltransferase Antikörper

Antigen: Alpha2, 6-Sialyltransferase

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN180239

Produktbeschreibung

Weitere Bezeichnung: alpha2,6-Sialyltransferase

Immunogen: The C-terminal part of synthetic peptide of Rat 2,6-sialyltransferase Purification: Purified with antigen peptide

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: The histopathological picture of Alzheimer's disease is characterized by senile plaques and neurofibrillary tangles, and because the senile plaques form first, they are considered the initial lesion. Senile plaques are known to be formed by accumulation of -amyloid peptide (A). A peptide is produced by the cleavage of amyloid precursor protein (APP) by two types of proteolytic enzymes. The first cleavage is performed by -secretase (BACE1), and the second -secretase. It is thought that their inhibitors may be capable of serving as safe drugs for the treatment of Alzheimer's disease. In recent years a glycosyltransferase involved in the biosynthesis of sugar chains (2,6-sialyltransferase) has also been shown to be cleaved by BACE1. The cleavage site was identified at the same time, and as a result it was demonstrated that in humans it produces cleavage-type 2,6-sialyltransferase (E44 Form) and in rats it produces cleavage-type 2,6-sialyltransferase (E41 Form). This product is purified antibody which can detect Rat 2,6-sialyltransferase (C-terminal).

Spezifität: Cross-reacts with Human, Mouse and Rat alpha2,6-sialyltransferase

Anwendungen

Applikationshinweise: This antibody can be used for western blotting in concentration of about 1-5ug/mL, however, the dilution rate should be optimized by each laboratories.

Reinigung: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 . Reconstitution: 1.0 mL distilled water will be added to the product, then its concentration comes to 100 ug/mL

Lagerung: Lyophilized product, 5 years at 2 ­ 8 : Solution, 2 years at ­20

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Alpha2, 6-Sialyltransferase antibody