RAB27B, Member RAS Oncogene Family (RAB27B) Antikörper

Antigen: RAB27B, Member RAS Oncogene Family (RAB27B)

Synonyme: 2310021G14Rik, B130064M09Rik, RAB27B, MGC80016, MGC79588

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN180233

Produktbeschreibung

Weitere Bezeichnung: Rab27B

Immunogen: Recombinant Rab27B protein

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Small GTPase Rab is a large family of membrane trafficking proteins that are conserved in all eukaryotic cells. More than 60 Rab isoforms have been reported in mice and humans, and they are believed to regulate various steps (or various types) of organelle transport. The Rab27 subfamily is phylogenetically similar to the Rab3 subfamily, and two Rab27 isoforms, Rab27A and Rab27B, are present in mice and humans. Mutations in the RAB27A gene cause human Griscelli syndrome, which is characterized by pigment dilution and immunodeficiency. The GTP-bound activated form of Rab27A regulates melanosome transport in melanocytes and secretory granule exocytosis (e.g., insulin secretion) through interaction with a specific effector molecule (e.g., Synaptotagmin-like protein (Slp) and Slac2). Rab27B is also expressed on secretory granules, the same as Rab27A, and regulates their exocytosis (e.g., amylase release from rat parotid acinar cells).

Spezifität: Cross-reacts with Mouse and Rat. Does not crossreact with to Rab3 subfamily

Anwendungen

Applikationshinweise: This antibody can be used for western blotting in concentration of about 1~5 ug/mL.

Reinigung: Recombinant human Rab27B

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 . Reconstitution: 1.0 ml distilled water will be added to the product, then its concentration comes to 100 ug/ml

Lagerung: Lyophilized product, 5 years at 2 ­ 8 : Solution, 2 years at ­20

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-RAB27B, Member RAS Oncogene Family (RAB27B) antibody