COX-2 Antikörper

Antigen: COX-2

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN180230

Produktbeschreibung

Immunogen: Synthetic peptide for a part of Rat COX-2 (DDINPTVLIKRRSTel) Purification: Affinity Purified with synthetic peptide

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Cyclooxygenase (COX) is a membrane bound enzyme responsible for the oxidation of arachidonic acid to Prostaglandin G2 (PGG2) and the subsequent reduction of PGG2 to PHG2. These reactions are the first steps in the formation of a variety of prostanoids. COX has been shown to be expressed in at least two different isoforms, a constitutively expressed form, COX-1, and an inducible form, COX-2. COX-1 is thought to regulate a number of housekeeping functions, such as vascular hemostasis, renal blood flow, and maintenance of glomerular function. Inflammation mediators such as growth factors, cytokines and endotoxin induce COX-2 expression in a number of cellular systems.

Anwendungen

Applikationshinweise: This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) method. The optimal dilution is about 5 ug/ml, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 5 ug/ml.

Reinigung: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 mL distilled water will be added to the product

Lagerung: Lyophilized product, 5 years at 2 ­ 8 C : Solution, 2 years at ­20 C

Forschungsgebiet: Krebs

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-COX-2 antibody

Gallbladder cancer of erbB2 transgenic mice