DNA Methyltransferase 1 (DNMT1) Antikörper

Antigen: DNA Methyltransferase 1 (DNMT1)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN180219

Produktbeschreibung

Weitere Bezeichnung: DNMT-1 (DNA Methyltransferase-1)

Immunogen: Synthetic peptide of C terminus of human DNMT-1 (MLAKARESASAKIKE) Purification: Purified with antigen peptide

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: The DNMT-1 is one of the enzymes responsible for methylation. Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. It is identified three families of mammalian DNA methyltransferase genes, which include DNMT-1, DNMT-2 and DNMT-3. The DNMT-1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality.

Spezifität: Confirmed by western blotting using Hela, SY and HT-29 cells

Anwendungen

Applikationshinweise: This antibody can be used for western blotting at about 2 ug/ml.

Reinigung: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 . Reconstitution: 1.0 ml distilled water will be added to the product, then its concentration comes to 100 ug/ml

Lagerung: Lyophilized product, 5 years at 2 ­ 8 C : Solution, 2 years at ­20 C

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-DNA Methyltransferase 1 (DNMT1) antibody