Prion Protein (PRNP) (N-Term) Antikörper

Antigen: Prion Protein (PRNP)

Synonyme: CJD, GSS, PrP, ASCR, PRIP, PrPc, CD230, prion, MGC26679, PrP27-30, PrP33-35C, Prn, MGC140197, prp, Prn-p, cjd, prp(c), MGC84114, PRNP, PRP, Prp, SIP, PRPC, DKFZp459A016

Epitope: N-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN180185

Produktbeschreibung

Weitere Bezeichnung: Prion Protein (N)

Immunogen: Synthetic peptide for N-terminal of Human Prion Protein Purification: Affinity Purified with synthetic peptide

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: The prion protein (Prp) is a protein of unknown function that is expressed in both normal cells and in cells affected by Transmissible spongioform encephalopathies (TSEs) which are lethal neurodegenerative diseases affecting numerous mammals. TSEs are characterized by the conversion of the cellular protein PrPC to the disease-associated variant, PrPSC. The PrPC and PrPSC proteins share the same primary sequence and have no known posttranslational differences, and are believed to differ in folding conformation. PrpSC is found in high quantity in the brains of animals affected by TSEs, including scrapie in sheep, BSE in cattle and Creutzfeld-Jacob disease in humans.

Spezifität: Confirmed by western blotting. Antigen peptide is 100% identical to Mouse, Rat, Gorilla and Chimpanzee. However, crossreactivities to those species are not tested.

Anwendungen

Applikationshinweise: This antibody can be stained in formalin fixed paraffin embedded tissues after autoclave treatment*1 by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 0.5·` 1 ug/ml, however, the dilution rate should be optimized by each laboratories. *1 Specimen should be put in 1mM HCl during autoclave treatment (121·Z , 1-0min) This antibody can be used for western blotting at 0.5 ug/ml.

Reinigung: Antigen Peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 0.5 ml distilled water will be added to the product

Lagerung: Lyophilized product, 5 years at 2 ­ 8 C : Solution, 2 years at ­20 C

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Prion Protein (PRNP) (N-Term) antibody