N-Cadherin(760) Antikörper

Antigen: N-Cadherin(760)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC)

Produktnummer: ABIN180177

Produktbeschreibung

Immunogen: Synthetic peptide of aa 746-761 (KRRDKERQAKQLLI) of human N-Cadherin Purification: Affinity purified with synthetic peptide

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Cadherins are a family of Ca2+-dependent intercellular adhesion molecules. They play an important role in cell-cell interaction, histogenesis and cellular transformation, and association with the actin cytoskeleton regulates their function by a complex of cytoplasmic proteins called the catenins (, , ). Among the cadherin protein family, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of -catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphory- lation events.

Anwendungen

Applikationshinweise: This antibody can be stained in formalin fixed paraffin embedded tissues after microwave treatment. The optimal dilution is 5 ug/ml, however, the dilution rate should be optimized by each laboratories.

Reinigung: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product

Lagerung: Lyophilized product, 5 years at 2 ­ 8 C : Solution, 2 years at ­20 C

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

human myocardium