GRO-a/MGSA (Melanoma Growth Stimulatory Activity Antikörper

Antigen: GRO-a/MGSA (Melanoma Growth Stimulatory Activity

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN180148

Produktbeschreibung

Immunogen: Synthetic peptide in portion of C-terminus of Human GRO/MGSA Purification: Purified with antigen peptide

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: GRO /MGSA as IL-8 family has the high homology with IL-8 in amino acid sequences. It is reported that it also has the similar configuration in 3D structural analysis and the almost same level of leukocyte chemotaxis with IL-8. Production from activated monocyte, fibroblast, epithelial and endothelial cells have been reported. In stomach mucosa infection of helicobacter pylori, gastritis and ulcer patients show significantly high level of IL-8 and GRO compared to non-infectious group. GRO is identified as a factor to promote melanoma cell propagation and is a polypeptide with 3 isoforms of , , and . GRO depresses the propagation of endothelial cells. As renal cancer has plenty of tumor blood vessels, it is important to identify the vascular formation factor and GRO is especially important in the formation of blood vessels.

Spezifität: No crossreactivities to Human GRO, Human IL-8, Human IP-10, Rat GRO/CINC-1, Rat GRO/CINC-2, Rat GRO/CINC-2 and Rat GRO/CINC-3.

Anwendungen

Applikationshinweise: This antibody can be stained in formalin fixed paraffin embedded tissues after trypsin pretreatment by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) method. The optimal dilution is about 5~10 g/ml, however, the dilution rate should be optimized by each laboratories.:This antibody can be used for western blotting in concentration of about 2~5 g/ml.

Reinigung: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 . Reconstitution: 1.0 ml distilled water will be added to the product

Lagerung: Lyophilized product, 5 years at 2 ­ 8 C : Solution, 2 years at ­20 C

Beschränkungen: Nur für Forschungszwecke einsetzbar