V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) Antikörper

Antigen: V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT)

Synonyme: PBT, SCFR, C-Kit, CD117, W, Bs, Fdc, Ssm, SCO1, SCO5, SOW3, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, c-kit, kit-A, XKrk1, KIT, MGF, LOC100221238, C-KIT

Klonalität: Monoklonal (12A8)

Wirt: Maus

Reaktivität: Human

Applikation: Western Blot (WB), Immunpräzipitation (IP), Durchflusszytometrie (FACS), Neutralisierung (Neut)

Produktnummer: ABIN180067

Produktbeschreibung

Weitere Bezeichnung: c-kit (12A8)

Immunogen: Recombinant protein of extracellular domain of human c-Kit

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 12A8

Beschreibung: The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor, and its ligand for c-Kit receptor has been identified as the stem cell factor (SCF). Recent experimental studies have shown that c-Kit plays a key role in the development of a component of the pacemaker system that is required for generation of autonomic gut motility. These studies further suggest that interaction of the c-Kit and SCF is essential for development of enteric nervous system. Recently, it is reported that the c-Kit may be an important marker for gastrointestinal stromal tumors (GISTs) which may originate from the interstitial cells of Cajal (ICCs). This monoclonal antibody recognizes c-Kit by W.B. and I.P. applications and it enables FACS analysis of c-Kit-expressing cells. It has been confirmed that the addition of this antibody does not induce ligand-binding-dependent phosphorylation of c-Kit and it may be used as a neutralizing antibody.

Spezifität: Confirmed by western blotting with SY cell.

Anwendungen

Applikationshinweise: This antibody can be used for western blotting at 1-5 ug/mL. This antibody can be used for immunoprecipitation at 3-5 ug/mL.

Reinigung: Protein A

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1.0 mL deionized water will be added to the product

Lagerung: Lyophilized product, 5 years at 2 ­ 8 : Solution, 2 years at ­20

Forschungsgebiet: Proliferationsmarker

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) antibody

anti-V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) antibody (Image 2)

anti-V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) antibody (Image 3)