Amyloid B (AA 11-28) Antikörper

Antigen: Amyloid B

Epitope: AA 11-28

Klonalität: Monoklonal (12B2)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN180023

Produktbeschreibung

Weitere Bezeichnung: Amyloid b (11-28)

Immunogen: Synthetic peptide for Human Amyloid [11-28]

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 12B2

Beschreibung: Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide(A), a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by beta-secretase and a putative secretase. Increased release of the `longer forms' of A peptide, A42 or A43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alles, or may involve other, still undiscovered, factors, Many researchers theorize that it is this increased release of A42/Abeta 43 which leads to the abnormal deposition of A and the associated neurotoxicity in the brains of affected individuals.

Spezifität: React with Human Amyloid[1-40], [1-42] and [1-43]

Anwendungen

Applikationshinweise: This antibody can be stained in formalin fixed paraffin embedded tissues after formic acid treatment*1 by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 0.251 ug/ml, however, the dilution rate should be optimized by each laboratories. *1 rinsing by running water after formic acid treatment for 5 minutes following de-paraffin. This antibody can be used for dot blotting in concentration of 2~5 ug /ml.

Reinigung: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 0.5 ml distilled water will be added to the product

Lagerung: Lyophilized product, 5 years at 2 ­ 8 : Solution, 2 years at ­20

Forschungsgebiet: Alzheimer-Krankheit (Morbus Alzheimer)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Human Brain (Alzheimer's Disease)

anti-Amyloid B (AA 11-28) antibody (Image 2)