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ApoE4 Antikörper

Details zu Produkt Nr. ABIN180022, Anbieter: Anmelden zum Anzeigen Neu
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Antigen
Reaktivität
Human
(12)
Wirt
Maus
(7), (5)
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
(1), (1), (1), (1), (1)
Applikation
Immunhistochemie (IHC), Western Blot (WB)
(12), (6), (4), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen Neu
Produkt-ID vom Hersteller Anmelden zum Anzeigen Neu
Menge 200 μg
Lieferung nach Deutschland ( )
Verfügbarkeit
Immunogen Synthetic peptide for a part of Human ApoE4
Klon 5B5
Isotyp IgG1
Spezifität Human ApoE4 specific, non-crossreactive with Human ApoE2 and ApoE3.
Reinigung Antigen peptide
Hintergrund Apolipoprotein-E (Apo-E) is a structural component of very low-density lipoprotein (VLDL) synthesized by the liver and intestinally synthesized chylomicrons. It is also a constituent of a subclass of high-density lipoproteins (HDLs) involved in cholesterol transport activity among cells. One of the most important roles of ApoE is to mediate high affinity binding of chylomicrons and VLDL particles that contain ApoE to the low-density lipoprotein (LDL) receptor. This allows for the specific uptake of these particles by the liver that is necessary for transport preventing the accumulation in plasma of cholesterol rich remnants. There are indications that ApoE is also involved in immune system regulation, nerve regeneration and muscle.
Applikationshinweise This antibody can be stained in formalin fixed paraffin embedded tissues after autoclave*1 (or microwave) treatment following formic acid treatment*2 by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1-020 ug/ml, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 1-0 ug /ml. *1 1-10 for 1-0 minutes (10mM citric acid buffer pH6.0) *2 Rinsing by running water after formic acid treatment for 5 minutes following de-paraffin.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Buffer Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Bilder des Herstellers
Immunhistochemie (IHC) image for anti-ApoE4 Antikörper (ABIN180022) Human Brain (Alzheimer Disease)
Western Blot (WB) image for anti-ApoE4 Antikörper (ABIN180022) anti-ApoE4 antibody (Image 2)
Produkt verwendet in: Kong, Bai, Sun et al.: "Expression of the Newly Identified Gene CAC1 in the Hippocampus of Alzheimer's Disease Patients." in: Journal of molecular neuroscience : MN, 2012 (PubMed).

Produktnummer ABIN180022

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