Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) Antikörper (PE)

Antigen: Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B)

Synonyme: DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNFSF13B, RGD1561519

Klonalität: Monoklonal (T7-241)

Wirt: Maus

Reaktivität: Human

Konjugat: PE

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN179907

Produktbeschreibung

Weitere Bezeichnung: CD257 (BAFF| BLYS)

Isotyp: IgG1, kappa chain

Klon: T7-241

Beschreibung: The T7-241 antibody recognizes human BAFF also known as B cell activating factor, tumor necrosis factor ligand superfamily 13B, B lymphocyte stimulator (BLYS), TNF and APOL-related leukocyte expressed ligand 1 (TALL1), and TNF homolog that activates apoptosis, NF-kappaB, and JNK (THANK). BAFF is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. BAFF can be proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homotrimers. The predicted molecular weight of a BAFF monomer is approximately 31 kD. BAFF is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and downregulated by PMA/ionomycin treatment. The T7-241 antibody has been shown to be useful for flow cytometry and ELISA. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors, BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3). The T7-241 antibody has been shown to be useful for flow cytometry and ELISA. Distribution: Peripheral blood B and T lymphocytes, monocytes, macrophages, dendritic cells. Upregulated by IFN-gamma downregulated by PMA/ionomycin treatment Function: Stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors. Prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3). Synonyms: BAFF, BLYS, TNFSF13b, B cell activating factor, tumor necrosis factor ligand superfamily 13B, B lymphocyte stimulator (BLYS), TNF and APOL-related leukocyte expressed ligand 1 (TALL1), TNF homolog that activates apoptosis, NF-kappaB and JNK (THANK) Structure: Type II transmembrane protein, member of the tumor necrosis factor ligand superfamily. Can be proteolytically cleaved to form soluble protein. Forms homotrimers, predicted molecular weight of monomer approximately 31 kD.

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 µl per million cells or 20 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Reinigung: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Lagerung: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) antibody (PE)