|
Beschreibung
|
The T3-6 antibody recognizes human APRIL (CD256) also known as A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2), TNF-related death ligand 1, and TNFSF13. APRIL is a member of the TNF superfamily, synthesized as a type II transmembrane protein, but cleaved by furin intracellularly to become secreted factor.. Several isoforms of APRIL can be produced by alternative splicing. APRIL, like other members of the TNF ligand superfamily, forms homodimers. The reported molecular weight of an APRIL monomer is approximately 27 kD. APRIL is highly expressed in transformed cell lines, cancers of colon, thyroid, and lymphoid tissues. Monocytes and macrophages also express APRIL, expression of APRIL is down-regulated following PMA/ionomycin treatment. APRIL has been implicated in B cell development and IgA class switching, T cell survival, and the stimulation of tumor cell growth. T3-6 antibody has been shown to be useful for flow cytometry and ELISA. Distribution: Highly expressed in transformed cell lines, cancers of colon, thyroid, and lymphoid tissues. Monocytes and macrophages express, down-regulated following PMA/ionomycin treatment Function: Has been implicated in B cell development and IgA class switching as well as T cell survival. Has also been reported to stimulate tumor cell growth. Synonyms: APRIL, TALL-2, A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2), TNF-related death ligand 1, TNFSF13 Structure: Member of the TNF superfamily, synthesized as a type II transmembrane protein, but cleaved by furin intracellularly to become secreted factor.. Several isoforms produced by alternative splicing. Forms homodimers, reported molecular weight of monomer approximately 27 kD
|
Alternativen 
