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Mannose Receptor, C Type 1 (MRC1) Antikörper (Alexa Fluor 647)
| Antigen | Mannose Receptor, C Type 1 (MRC1) |
| Synonyme | MMR, CD206, CLEC13D, MR, AW259686, mrc1, MGC86525, MRC1L1, MRC1 |
| Klonalität | Monoklonal (MR5D3) |
| Wirt |
 Alternativen Ratte |
| Reaktivität |
Alternativen Maus |
| Konjugat |
Alternativen Alexa Fluor 647 |
| Applikation |
Alternativen Durchflusszytometrie (FACS)
|
| Produktnummer | ABIN179831 |
| Menge | 100 µg (Varianten) |
| Preis | Produkt für diese Region nicht verfügbar. |
| Lieferung nach |
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Produktbeschreibung
| Weitere Bezeichnung | CD206 (MMR) |
| Immunogen | Mannose Receptor CRD4-7-Fc fusion protein |
| Isotyp | IgG2a, kappa chain |
| Klon | MR5D3 |
| Beschreibung | CD206, known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belongs to C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, langerhans cells and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis, as well as activation of macrophages and antigen presentation, and plays an important role in host defense and provides a link between innate and adaptive immunity Distribution: Macrophages, dendritic cells, Langerhans cells, liver endothelial cells Function: Pathogen recognition, endocytosis and phagocytosis, antigen presentation Synonyms: MMR (macrophage mannose receptor), MR (mannose receptor), CD206, MRC1 Structure: Type I transmembrane protein, 175 kD, C-type lectin superfamily |
Anwendungen
| Applikationshinweise | Additional reported applications (for the relevant formats) include: immunoprecipitation, Western blotting, and immunohistochemical staining of frozen sections. Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is < 1.0 µg per 10 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm. ** Alexa Fluor® is a registered trademark of Molecular Probes, Inc. Alexa Fluor® dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents. |
| Reinigung | The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 647. |
| Buffer | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Lagerung | The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Forschungsgebiet | CD Antigene |
| Beschränkungen | Nur für Forschungszwecke einsetzbar |
Alternativen
Alternativen zu Antigen "Mannose Receptor, C Type 1 (MRC1)", Typ "Antikörper" finden
| Wirte | Maus (27), Ratte (15) |
| Reaktivitäten | Human (28), Maus (15), Ratte (Rattus) (1) |
| Applikationen | Durchflusszytometrie (FACS) (28), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (17), Western Blot (WB) (16), Immunpräzipitation (IP) (6), Enzyme Immunoassay (EIA) (4), Immunfluoreszenz (IF) (2), Immunhistochemie (IHC) (2), Immunhistochemie (Paraffinschnitte) (IHC (p)) (2) |
| Konjugate | Biotin (6), FITC (5), Alexa Fluor 488 (4), PE (3), APC (2), APC,Cy7 (2), Alexa Fluor 647 (2), PE,Cy5 (1) |
