P2RX7 Antikörper (C-Term)

Produktnummer ABIN1742370

Produktdetails anti-P2RX7 Antikörper

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Bindungsspezifität: AA 363-595, C-Term

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser P2RX7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Specific for P2X7.

Aufreinigung: Affinity purified with the immunogen. Rabbit serum albumin was added for stabilization.

Immunogen: Recombinant cytoplasmic C-terminal tail of mouse P2X7 (aa 363-595).

Anwendungsinformationen

Applikationshinweise: WB: 1 : 1000 (AP staining)
IP: not tested yet
ICC: not tested yet
IHC: not tested yet

Kommentare:

Detects mouse protein with higher sensitivity. This antibody detects an additional band at 30 kDa of unknown identity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: For reconstitution add 50 µL H2O to get a 1mg/ml solution of antibody in PBS. Then aliquot and store at -20 °C until use.

Buffer: PBS

Handhabung: Affinity purified antibodies are less robust than antisera, since protease inhibitors are also removed during purification. Hence, storage at 4 °C for prolonged periods (i.e. several weeks), is not recommended.

Lagerung: -20 °C

Informationen zur Lagerung: Unlabeled lyophilized antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4°C for several years. Lyophilized antibodies must not be stored in the freezer, they may be destroyed!

Referenzen für anti-P2RX7 Antikörper (ABIN1742370)

Young, Sinadinos, Lefebvre, Chan, Arkle, Vaudry, Gorecki: "A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90." in: Autophagy, Vol. 11, Issue 1, pp. 113-30, (2015) (PubMed).

Young, Brutkowski, Lien, Arkle, Lochmüller, Zabłocki, Górecki: "P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment." in: Journal of cellular and molecular medicine, Vol. 16, Issue 5, pp. 1026-37, (2012) (PubMed).

Masin, Young, Lim, Barnes, Xu, Marschall, Brutkowski, Mooney, Gorecki, Murrell-Lagnado: "Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts." in: British journal of pharmacology, Vol. 165, Issue 4, pp. 978-93, (2012) (PubMed).

Details zu P2RX7

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Andere Bezeichnung: P2X7 (P2RX7 Produkte)

Synonyme: p2xr7 antikoerper, P2RX7 antikoerper, P2X7 antikoerper, AI467586 antikoerper, P2X(7) antikoerper, P2X7R antikoerper, p2x7 antikoerper, purinergic receptor P2X 7 antikoerper, purinergic receptor P2X, ligand-gated ion channel, 7 antikoerper, P2X purinoceptor 7 antikoerper, P2RX7 antikoerper, p2rx7 antikoerper, LOC100458463 antikoerper, P2rx7 antikoerper

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis