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Transferrin Receptor Antikörper (AA 608-727)

Name: Transferrin Receptor Antikörper (AA 608-727)
Brand: antibodies-online
SKU: ABIN1724899
Price: 614.71 EUR
Availability: InStock

TFRC Reaktivität: Human, Maus, Ratte, Affe WB, ELISA Wirt: Maus Monoclonal 1A1B2 unconjugated

Western blot analysis using TFRC mouse mAb against Jurkat (1), Hela (2), K562 (3), Cos7 (4), MCF-7 (5), PC-12 (6), NIH/3T3 (7), HEK293 (8), RAJI (9) cell lysate.

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng),

ELISA

Western blot analysis using TFRC mAb against human TFRC recombinant protein.

Western blot analysis using TFRC mAb against HEK293 (1) and TFRC (AA: 608-727)-hIgGFc transfected HEK293 (2) cell lysate.

4 Abbildungen

(2 Referenzen)

Produktnummer ABIN1724899

Datenblatt (PDF)

Target Alle Transferrin Receptor (TFRC) Antikörper anzeigen

Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
Bindungsspezifität
16

15

10

8

8

7

6

6

6

5

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 608-727
Reaktivität
195

80

27

7

5

4

2

2

2

1

1

1

1
Human, Maus, Ratte, Affe
Wirt
110

108

31

1

1
Maus
Passende Sekundärantikörper
Klonalität
155

94

1
Monoklonal
Konjugat
110

27

20

15

10

5

5

4

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
Dieser Transferrin Receptor Antikörper ist unkonjugiert
Applikation
154

138

72

67

54

41

24

21

19

12

7

6

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1
Western Blotting (WB), ELISA

Aufreinigung

purified

Immunogen

Purified recombinant fragment of human TFRC (AA: 608-727) expressed in E. coli.

Klon

1A1B2

Isotyp

IgG1

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anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 572-757) antibody
TFRC Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 567-744) antibody
TFRC Reaktivität: Human WB, IHC, IP, ICC Wirt: Maus Monoclonal unconjugated

Applikationshinweise

ELISA: 1:10000, WB: 1:500 - 1:2000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

4°C, -20°C for long term storage
Płoszyńska, Ruckemann-Dziurdzińska, Jóźwik, Mikosik, Lisowska, Balcerska, Witkowski: "Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia." in: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, Vol. 50, Issue 2, pp. 304-11, (2012) (PubMed).

Jian, Yang, Huang: "Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival." in: The Journal of biological chemistry, Vol. 286, Issue 41, pp. 35708-15, (2011) (PubMed).
Target

Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Andere Bezeichnung

TFRC (TFRC Produkte)

Synonyme

Trfr antikoerper, LOC100219280 antikoerper, tfr antikoerper, cd71 antikoerper, tfr1 antikoerper, trfr antikoerper, CD71 antikoerper, T9 antikoerper, TFR antikoerper, TFR1 antikoerper, TR antikoerper, TRFR antikoerper, p90 antikoerper, 2610028K12Rik antikoerper, AI195355 antikoerper, AI426448 antikoerper, AU015758 antikoerper, E430033M20Rik antikoerper, Mtvr-1 antikoerper, Mtvr1 antikoerper, transferrin receptor antikoerper, TFRC antikoerper, Tfrc antikoerper, tfrc antikoerper

Hintergrund

Description: Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. Expression of human TFR1, but not human TFR2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the glycoprotein of Machupo, Guanarito, and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TFR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin, and Sabia viruses, but not that of Lassa virus.TFR1 is a cellular receptor for New World hemorrhagic fever arenaviruses. , ,
Aliases: T9, TR, TFR, p90, CD71, TFR1, TRFR

Molekulargewicht

85 kDa

Gen-ID

7037

HGNC

7037

Pathways

Transition Metal Ion Homeostasis