CA9 Antikörper (AA 37-186)

Produktnummer ABIN1724883

Produktdetails anti-CA9 Antikörper

Target: CA9 (Carbonic Anhydrase IX (CA9))

Bindungsspezifität: AA 37-186

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CA9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human CA9 (AA: 37-186) expressed in E. coli.

Klon: 7C4A5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-CA9 Antikörper (ABIN1724883)

Neumeister, Sullivan, Lindner, Lezon-Geyda, Li, Zavada, Martel, Glazer, Tuck, Rimm, Harris: "Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer." in: Breast cancer research and treatment, Vol. 136, Issue 1, pp. 67-75, (2012) (PubMed).

Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: "GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression." in: Histology and histopathology, Vol. 26, Issue 10, pp. 1279-86, (2011) (PubMed).

Details zu CA9

Target: CA9 (Carbonic Anhydrase IX (CA9))

Andere Bezeichnung: CA9 (CA9 Produkte)

Synonyme: CA9 antikoerper, CAIX antikoerper, Ca9 antikoerper, MN/CA9 antikoerper, MN antikoerper, carbonic anhydrase 9 antikoerper, CA9 antikoerper, CAH9 antikoerper, Car9 antikoerper

Hintergrund:

Description: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. ,

Aliases: MN, CAIX

Molekulargewicht: 49.7 kDa

Gen-ID: 768

HGNC: 768