Calreticulin Antikörper

Produktnummer ABIN1724687

Produktdetails anti-Calreticulin Antikörper

Target: Calreticulin (CALR)

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Calreticulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Sequenz: EEEDVPGQAK DELC

Immunogen: Synthetic peptide corresponding to aa (EEEDVPGQAKDELC) of human Calreticulin, conjugated to KLH.

Klon: 1G6A7

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-Calreticulin Antikörper (ABIN1724687)

Tan, Chen, Li, Mabuchi, Bouvier: "The calcium- and zinc-responsive regions of calreticulin reside strictly in the N-/C-domain." in: Biochimica et biophysica acta, Vol. 1760, Issue 5, pp. 745-53, (2006) (PubMed).

Details zu Calreticulin

Target: Calreticulin (CALR)

Andere Bezeichnung: Calreticulin (CALR Produkte)

Synonyme: CRT antikoerper, RO antikoerper, SSA antikoerper, cC1qR antikoerper, crc antikoerper, crt antikoerper, Calregulin antikoerper, CG9429 antikoerper, Clr antikoerper, Dmel\\CG9429 antikoerper, anon-EST:Liang-2.11 antikoerper, anon-EST:Liang-2.17 antikoerper, anon-EST:fe3D7 antikoerper, clone 2.11 antikoerper, clone 2.17 antikoerper, eth antikoerper, potp antikoerper, cc1qr antikoerper, ssa antikoerper, NV19007 antikoerper, CRP55 antikoerper, ERp60 antikoerper, HACBP antikoerper, CHOT1 antikoerper, CHT1 antikoerper, CT1 antikoerper, AA589632 antikoerper, CRTR antikoerper, Creat antikoerper, CCDS1 antikoerper, calrl2 antikoerper, fc66d10 antikoerper, wu:fc66d10 antikoerper, wu:fj50c03 antikoerper, zgc:66153 antikoerper, calreticulin antikoerper, calreticulin L homeolog antikoerper, Calreticulin antikoerper, putative calreticulin antikoerper, solute carrier family 6 member 8 antikoerper, solute carrier family 6 (neurotransmitter transporter, creatine), member 8 antikoerper, CALR antikoerper, calr.L antikoerper, Crt antikoerper, crt antikoerper, CRT antikoerper, Calr antikoerper, calr antikoerper, LMJF_31_2600 antikoerper, Crc antikoerper, Slc6a8 antikoerper, SLC6A8 antikoerper, LOC8269812 antikoerper

Hintergrund:

Description: Calreticulin, also known as RO, CRT, SSA, cC1qR, FLJ26680, CALR. Entrez Protein NP_004334. It is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

Aliases: RO, CRT, SSA, cC1qR, FLJ26680, CALR

Molekulargewicht: 48 kDa

Gen-ID: 811

NCBI Accession: NP_004334

HGNC: 811

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response