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GSK3 alpha Antikörper

GSK3a Reaktivität: Human WB, ELISA, ICC Wirt: Maus Monoclonal 9D5G1 unconjugated
Produktnummer ABIN1724666
  • Target Alle GSK3 alpha (GSK3a) Antikörper anzeigen
    GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
    Reaktivität
    • 103
    • 84
    • 66
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 116
    • 21
    • 2
    Maus
    Klonalität
    • 113
    • 28
    Monoklonal
    Konjugat
    • 75
    • 11
    • 10
    • 8
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GSK3 alpha Antikörper ist unkonjugiert
    Applikation
    • 112
    • 64
    • 58
    • 21
    • 20
    • 16
    • 13
    • 13
    • 6
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of GSK3 alpha expressed in E. coli.
    Klon
    9D5G1
    Isotyp
    IgG1
    Top Product
    Discover our top product GSK3a Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Mendez, Garcia-Segura: "Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells." in: Endocrinology, Vol. 147, Issue 6, pp. 3027-39, (2006) (PubMed).

    Bianchi, De Lucchini, Marin, Turner, Hanks, Villa-Moruzzi: "Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration." in: The Biochemical journal, Vol. 391, Issue Pt 2, pp. 359-70, (2005) (PubMed).

    De Servi, Hermani, Medunjanin, Mayer: "Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells." in: Oncogene, Vol. 24, Issue 31, pp. 4946-55, (2005) (PubMed).

  • Target
    GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
    Andere Bezeichnung
    GSK3 alpha (GSK3a Produkte)
    Synonyme
    2700086H06Rik antikoerper, GSK3A antikoerper, GSK-3[a] antikoerper, GSK-3[b] antikoerper, GSK3 antikoerper, gsk3a antikoerper, xgsk3 antikoerper, glycogen synthase kinase 3 alpha antikoerper, glycogen synthase kinase 3 alpha b antikoerper, glycogen synthase kinase 3 alpha S homeolog antikoerper, GSK3A antikoerper, Gsk3a antikoerper, gsk3a antikoerper, gsk3ab antikoerper, gsk3a.S antikoerper, Bm1_31380 antikoerper
    Hintergrund

    Description: Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97 % sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

    Aliases: DKFZp686D0638, GSK3A

    Gen-ID
    2931
    HGNC
    2931
    Pathways
    PI3K-Akt Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effekt
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