GATA2 Antikörper (pSer401) (HRP)

Produktnummer ABIN1712589

Produktdetails anti-GATA2 Antikörper (HRP)

Target: GATA2 (GATA Binding Protein 2 (GATA2))

Bindungsspezifität: pSer401

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GATA2 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human

Homologie: Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human GATA2 around the phosphorylation site of Ser401

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GATA2

Target: GATA2 (GATA Binding Protein 2 (GATA2))

Andere Bezeichnung: GATA2 (GATA2 Produkte)

Synonyme: DCML antikoerper, MONOMAC antikoerper, NFE1B antikoerper, Gata-2 antikoerper, xgata-2 antikoerper, xgata2 antikoerper, GATA-2 antikoerper, NF-E1b antikoerper, GATA2 antikoerper, Gata2 antikoerper, gata2 antikoerper, zg2 antikoerper, zgc:91840 antikoerper, GATA binding protein 2 antikoerper, GATA binding protein 2 L homeolog antikoerper, amidase antikoerper, glutamyl/aspartyl-tRNA(Gln/Asp) amidotransferasesubunit A antikoerper, hypothetical protein antikoerper, glutamyl-tRNA(Gln) amidotransferase, subunit GatA (Glu-ADT subunit A) antikoerper, GATA2 transcription factor antikoerper, putative gata binding factor antikoerper, GATA binding protein 2a antikoerper, GATA binding protein 2b antikoerper, GATA2 antikoerper, Gata2 antikoerper, gata2.L antikoerper, RR_RS20245 antikoerper, gatA2 antikoerper, Smp_018590 antikoerper, gata2a antikoerper, gata2b antikoerper

Hintergrund:

Synonyms: GATA2 phospho S401, p-GATA2 phospho S401, GATA-2, GATA 2, GATA Binding Protein 2, GATA-binding protein 2, Gata2, GATA2_HUMAN, MGC2306, NFE 1B, NFE1B.

Background: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary, lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

Gen-ID: 2624

Pathways: Stem Cell Maintenance