SMAD1 Antikörper (pSer463) (HRP)

Produktnummer ABIN1712477

Produktdetails anti-SMAD1 Antikörper (HRP)

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Bindungsspezifität: pSer463

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Smad1 around the phosphorylation site of Ser463

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SMAD1

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Andere Bezeichnung: Smad1 (SMAD1 Produkte)

Synonyme: MLP antikoerper, Xmad1 antikoerper, Xsmad1 antikoerper, bsp1 antikoerper, jv4-1 antikoerper, jv41 antikoerper, madh1 antikoerper, madr1 antikoerper, smad-1 antikoerper, MADH1 antikoerper, fb39h09 antikoerper, wu:fb39h09 antikoerper, wu:fb97e04 antikoerper, 2/23 antikoerper, CG12399 antikoerper, Dmel\\CG12399 antikoerper, E(zen)2 antikoerper, En(vvl) antikoerper, MAD antikoerper, Mat antikoerper, P-Mad antikoerper, P-mad antikoerper, PMad antikoerper, Smad antikoerper, Smad1 antikoerper, apg antikoerper, c28 antikoerper, dMAD antikoerper, dMad antikoerper, l(2)K00237 antikoerper, l(2)k00237 antikoerper, mad antikoerper, p-Mad antikoerper, pMAD antikoerper, pMad antikoerper, pSmad antikoerper, BSP-1 antikoerper, BSP1 antikoerper, JV4-1 antikoerper, JV41 antikoerper, MADR1 antikoerper, AI528653 antikoerper, Madh1 antikoerper, Madr1 antikoerper, Mlp1 antikoerper, MusMLP antikoerper, smad1 antikoerper, xmad antikoerper, SMAD family member 1 antikoerper, Mothers against dpp antikoerper, SMAD family member 1 L homeolog antikoerper, smad1 antikoerper, SMAD1 antikoerper, Mad antikoerper, Smad1 antikoerper, smad1.L antikoerper

Hintergrund:

Synonyms: Smad1 phospho S463, Smad1 phospho Ser463, p-Smad1 Ser463, Mothers against decapentaplegic homolog 1, BSP 1, BSP1, BSP-1, Dwarfin A, DwfA, hSMAD 1, hSMAD1, JV 41, JV4 1, JV4-1, JV41, MAD mothers against decapentaplegic homolog 1, Mad related protein 1, MADH 1, MADH1, Madr 1, MADR1, Mothers against decapentaplegic homolog 1, Mothers against DPP homolog 1, Sma and Mad related protein 1, SMAD 1, SMAD-1, SMAD family member 1, SMAD mothers against DPP homolog 1 Drosophila, Spinal muscular atrophy distal with upper limb predominance, TGF beta signaling protein 1, Transforming growth factor beta signaling protein 1, SMAD1_HUMAN, MAD homolog 1, Mothers against DPP homolog 1, Mad-related protein 1, SMAD family member 1, Smad1, Transforming growth factor-beta-signaling protein 1.

Background: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].

Gen-ID: 4086

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development