TNFRSF11A Antikörper (AA 101-200) (HRP)

Produktnummer ABIN1712150

Produktdetails anti-TNFRSF11A Antikörper (HRP)

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Bindungsspezifität: AA 101-200

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF11A Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Sheep,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RANK

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu TNFRSF11A

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Andere Bezeichnung: Rank (TNFRSF11A Produkte)

Synonyme: RANK antikoerper, RGD1563614 antikoerper, TNFRSF11A antikoerper, Ly109 antikoerper, ODFR antikoerper, OFE antikoerper, Rank antikoerper, TRANCE-R antikoerper, mRANK antikoerper, CD265 antikoerper, FEO antikoerper, LOH18CR1 antikoerper, OPTB7 antikoerper, OSTS antikoerper, PDB2 antikoerper, TRANCER antikoerper, TNF receptor superfamily member 11A antikoerper, TNF receptor superfamily member 11a antikoerper, tumor necrosis factor receptor superfamily, member 11a, NFKB activator antikoerper, Tnfrsf11a antikoerper, TNFRSF11A antikoerper

Hintergrund:

Synonyms: TNFRSF11A, CD 265, CD265, CD265 antigen, Activator of NFKB, EOF, FEO, mRANK, NFKB activator, ODFR, OFE, Osteoclast dferentiation factor receptor, PDB 2, Receptor activator of NF KB, receptor activator of nuclear factor kappa B, TNFRSF 11A, TNFSF11, TRANCE R, RANK receptor, TNR11_HUMAN.

Background: CD265 is a member of the tumor necrosis factor receptor (TNFR) family. Human and murine CD265 share 81 % amino acid identity in their extracellular domains. CD265 is widely expressed, with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. CD265 is also expressed in dendritic cells. RANK and RANK ligand (RANKL) are important regulators of interactions between T cells and dendritic cells. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of CD265. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for CD265. The biological functions mediated by RANK include activation of NFkappaB and cjun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis. The soluble form of CD265 is able to block TRANCE induced biological activity. The binding of anti-CD265 to cell surface CD265 triggers signal transduction and induces CD265 mediated bioactivity.

Pathways: NF-kappaB Signalweg