APC2 Antikörper (AA 1-100) (HRP)

Produktnummer ABIN1712105

Produktdetails anti-APC2 Antikörper (HRP)

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Bindungsspezifität: AA 1-100

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APC2 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APCL/APC2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu APC2

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Andere Bezeichnung: APCL/APC2 (APC2 Produkte)

Synonyme: APCL antikoerper, AI852447 antikoerper, R75424 antikoerper, APC2, WNT signaling pathway regulator antikoerper, adenomatosis polyposis coli 2 antikoerper, APC2 antikoerper, Apc2 antikoerper

Hintergrund:

Synonyms: Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, APCL, APC2_HUMAN.

Background: The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner?s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin.

Gen-ID: 10297

Pathways: WNT Signalweg