LAMTOR2 Antikörper (AA 3-100) (Cy5.5)
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- Target Alle LAMTOR2 Antikörper anzeigen
- LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
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Bindungsspezifität
- AA 3-100
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser LAMTOR2 Antikörper ist konjugiert mit Cy5.5
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Dog,Cow
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human ROBLD3
- Isotyp
- IgG
- Top Product
- Discover our top product LAMTOR2 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
- Andere Bezeichnung
- Robld3 (LAMTOR2 Produkte)
- Synonyme
- ENDAP antikoerper, HSPC003 antikoerper, MAPBPIP antikoerper, MAPKSP1AP antikoerper, ROBLD3 antikoerper, Ragulator2 antikoerper, p14 antikoerper, 2010111E04Rik antikoerper, AL022628 antikoerper, Mapbpip antikoerper, P14 antikoerper, Rab25 antikoerper, Robld3 antikoerper, RGD1562501 antikoerper, cg5189 antikoerper, endap antikoerper, hspc003 antikoerper, mapbpip antikoerper, mapbpip-B antikoerper, mapksp1ap antikoerper, ragulator2 antikoerper, robld3 antikoerper, robld3-b antikoerper, zgc:100811 antikoerper, lamtor2 antikoerper, lamtor2-a antikoerper, lamtor2-b antikoerper, mapbpip-A antikoerper, robld3-a antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 S homeolog antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 L homeolog antikoerper, LAMTOR2 antikoerper, Lamtor2 antikoerper, lamtor2.S antikoerper, lamtor2 antikoerper, lamtor2.L antikoerper
- Hintergrund
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Synonyms: ENDAP, Endosomal adaptor protein p14, HSPC003, LAMTOR2, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Late endosomal/lysosomal Mp1 interacting protein, Late endosomal/lysosomal Mp1-interacting protein, LTOR2_HUMAN, MAPBPIP, MAPKSP1 adaptor protein, MAPKSP1AP, Mitogen activated protein binding protein interacting protein, Mitogen-activated protein-binding protein-interacting protein, p14, Ragulator complex protein LAMTOR2, Ragulator2, Roadblock domain containing 3, Roadblock domain containing protein 3, Roadblock domain-containing protein 3, ROBLD 3, RP11 336K24.9.
Background: MP1 (MEK partner 1) functions as a scaffolding protein in the mitogen activated protein (MAP) kinase signaling pathway. Growth factor induced MAP kinase activation is selectively mediated by the extracellular signal-regulated kinase (ERK) cascade. MAPBPIP (mitogen-activated protein-binding protein-interacting protein), also known as p14 and late endosomal/lysosomal MP1-interacting protein, functions as an adaptor protein augmenting the regulation of the MAP kinase cascade. Partner proteins MAPBPIP and MP1 are structurally almost identical each with a five-stranded -sheet flanked between a two-helix and one-helix layer. MAPBPIP compels the recruitment of MP1 to late endosomes where they form a very stable heterodimeric complex required for ERK activation on endosomes. Knockdown of the individual proteins in the MP1/MAPBPIP complex resulted in decreased expression of the partner proteins which implies greater stability of the heterodimeric complex than either MP1 or MAPBPIP individually. Early research suggests the MP1-MAPBPIP-MEK-1 signaling complex may be critical in the regulation of tissue homeostasis.
- Pathways
- PI3K-Akt Signalweg
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