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LAMTOR2 Antikörper (AA 3-100) (Cy3)

LAMTOR2 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN1702881
  • Target Alle LAMTOR2 Antikörper anzeigen
    LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
    Bindungsspezifität
    • 14
    • 7
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    AA 3-100
    Reaktivität
    • 36
    • 9
    • 1
    Human
    Wirt
    • 36
    Kaninchen
    Klonalität
    • 36
    Polyklonal
    Konjugat
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser LAMTOR2 Antikörper ist konjugiert mit Cy3
    Applikation
    • 16
    • 14
    • 12
    • 12
    • 12
    • 6
    • 3
    • 2
    • 2
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ROBLD3
    Isotyp
    IgG
    Top Product
    Discover our top product LAMTOR2 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
    Andere Bezeichnung
    Robld3 (LAMTOR2 Produkte)
    Synonyme
    ENDAP antikoerper, HSPC003 antikoerper, MAPBPIP antikoerper, MAPKSP1AP antikoerper, ROBLD3 antikoerper, Ragulator2 antikoerper, p14 antikoerper, 2010111E04Rik antikoerper, AL022628 antikoerper, Mapbpip antikoerper, P14 antikoerper, Rab25 antikoerper, Robld3 antikoerper, RGD1562501 antikoerper, cg5189 antikoerper, endap antikoerper, hspc003 antikoerper, mapbpip antikoerper, mapbpip-B antikoerper, mapksp1ap antikoerper, ragulator2 antikoerper, robld3 antikoerper, robld3-b antikoerper, zgc:100811 antikoerper, lamtor2 antikoerper, lamtor2-a antikoerper, lamtor2-b antikoerper, mapbpip-A antikoerper, robld3-a antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 S homeolog antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 L homeolog antikoerper, LAMTOR2 antikoerper, Lamtor2 antikoerper, lamtor2.S antikoerper, lamtor2 antikoerper, lamtor2.L antikoerper
    Hintergrund

    Synonyms: ENDAP, Endosomal adaptor protein p14, HSPC003, LAMTOR2, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Late endosomal/lysosomal Mp1 interacting protein, Late endosomal/lysosomal Mp1-interacting protein, LTOR2_HUMAN, MAPBPIP, MAPKSP1 adaptor protein, MAPKSP1AP, Mitogen activated protein binding protein interacting protein, Mitogen-activated protein-binding protein-interacting protein, p14, Ragulator complex protein LAMTOR2, Ragulator2, Roadblock domain containing 3, Roadblock domain containing protein 3, Roadblock domain-containing protein 3, ROBLD 3, RP11 336K24.9.

    Background: MP1 (MEK partner 1) functions as a scaffolding protein in the mitogen activated protein (MAP) kinase signaling pathway. Growth factor induced MAP kinase activation is selectively mediated by the extracellular signal-regulated kinase (ERK) cascade. MAPBPIP (mitogen-activated protein-binding protein-interacting protein), also known as p14 and late endosomal/lysosomal MP1-interacting protein, functions as an adaptor protein augmenting the regulation of the MAP kinase cascade. Partner proteins MAPBPIP and MP1 are structurally almost identical each with a five-stranded -sheet flanked between a two-helix and one-helix layer. MAPBPIP compels the recruitment of MP1 to late endosomes where they form a very stable heterodimeric complex required for ERK activation on endosomes. Knockdown of the individual proteins in the MP1/MAPBPIP complex resulted in decreased expression of the partner proteins which implies greater stability of the heterodimeric complex than either MP1 or MAPBPIP individually. Early research suggests the MP1-MAPBPIP-MEK-1 signaling complex may be critical in the regulation of tissue homeostasis.

    Pathways
    PI3K-Akt Signalweg
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