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CD200 Antikörper (APC)

CD200 Reaktivität: Human FACS Wirt: Maus Monoclonal OX-104 APC
Produktnummer ABIN1690745
  • Target Alle CD200 Antikörper anzeigen
    CD200
    Reaktivität
    • 92
    • 25
    • 22
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 57
    • 49
    • 15
    Maus
    Klonalität
    • 59
    • 59
    Monoklonal
    Konjugat
    • 41
    • 14
    • 14
    • 11
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD200 Antikörper ist konjugiert mit APC
    Applikation
    • 55
    • 55
    • 33
    • 26
    • 16
    • 14
    • 13
    • 10
    • 8
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody OX-104 recognizes an extracellular epitope of CD200, a type-1 glycoprotein of the immunoglobulin superfamily, which is expressed in neurons, B and T cell subsets, keratinocytes, follicular dendritic cells, and ovarian cells.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    recombinant human CD200
    Klon
    OX-104
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product CD200 Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Colmont, Benketah, Reed, Hawk, Telford, Ohyama, Udey, Yee, Vogel, Patel: "CD200-expressing human basal cell carcinoma cells initiate tumor growth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 4, pp. 1434-9, (2013) (PubMed).

    Li, Zhao, Tong, Qian, Ren, Zhang, Ding, Chen, Wang, Zhang, Zeng, Zhang, Tang, Zhang, Ba, He, Cao, Lipsky: "Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity." in: Arthritis research & therapy, Vol. 14, Issue 3, pp. R123, (2012) (PubMed).

    Garza, Yang, Zhao, Blatt, Lee, He, Stanton, Carrasco, Spiegel, Tobias, Cotsarelis: "Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells." in: The Journal of clinical investigation, Vol. 121, Issue 2, pp. 613-22, (2011) (PubMed).

    Meuth, Simon, Grimm, Melzer, Herrmann, Spitzer, Landgraf, Wiendl: "CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing." in: Journal of neuroimmunology, Vol. 194, Issue 1-2, pp. 62-9, (2008) (PubMed).

    Sopp, Werling, Baldwin: "Cross-reactivity of mAbs to human CD antigens with cells from cattle." in: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 106-14, (2007) (PubMed).

    Shiratori, Yamaguchi, Suzukawa, Yamamoto, Lanier, Saito, Arase: "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 7, pp. 4441-9, (2005) (PubMed).

    Foster-Cuevas, Wright, Puklavec, Brown, Barclay: "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor." in: Journal of virology, Vol. 78, Issue 14, pp. 7667-76, (2004) (PubMed).

  • Target
    CD200
    Andere Bezeichnung
    CD200 (CD200 Produkte)
    Synonyme
    MOX1 antikoerper, MOX2 antikoerper, MRC antikoerper, OX-2 antikoerper, CD200 antikoerper, Cspmo2 antikoerper, MRCOX2 antikoerper, Mox2 antikoerper, DKFZp459C0716 antikoerper, OX2 antikoerper, CD200 molecule antikoerper, Cd200 molecule antikoerper, CD200 antigen antikoerper, CD200 antikoerper, Cd200 antikoerper
    Hintergrund
    CD200 Molecule,CD200 (also known as OX2 or MRC) is a type-1 membrane glycoprotein, which contains two extracellular immunoglobulin domains, transmembrane domain and cytoplasmic domain. It is expressed by neuronal cells, B and T cell subsets, follicular dendritic cells, keratinocytes, and ovarian cells. The interaction between CD200 and its receptor CD200R results in macrophage activation (IL-6 production), inhibition of mast cell degranulation along with reduced TNF-alpha and IL-13 secretion and overall attenuation of the activation status of lymphocytes. It seems CD200 is also involved in maternal tolerance and its decreased expression in hair follicle correlates with follicular miniaturization.,MRC, MOX, OX-2
    Gen-ID
    4345
    UniProt
    P41217
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