LYVE1 Antikörper
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- Target Alle LYVE1 Antikörper anzeigen
- LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser LYVE1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- Recombinant human LYVE-1
- Produktmerkmale
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Chromosomal location: 11p15
Produced from sera of rabbits immunized with highly pure recombinant human soluble LYVE-1 produced in insect cells. The recombinant soluble LYVE-1consists of amino acid 24 (Ser) to 232 (Gly) and is fused to a C-terminal His-tag (6xHis). LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. - Isotyp
- IgG
- Top Product
- Discover our top product LYVE1 Primärantikörper
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- Applikationshinweise
- Western Blot: use 2-5 µg/mL
- Kommentare
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Rabbit IG Polyclonal Antibody
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- Buffer
- PBS
- Handhabung
- Centrifuge vial prior to opening.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
- Haltbarkeit
- 6 months
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Development of full-thickness human skin equivalents with blood and lymph-like capillary networks by cell coating technology." in: Journal of biomedical materials research. Part A, (2015) (PubMed).
: "Lymphangiogenesis and angiogenesis during human fetal pancreas development." in: Vascular cell, Vol. 6, pp. 22, (2015) (PubMed).
: "Molecular and cellular effects of in vitro shockwave treatment on lymphatic endothelial cells." in: PLoS ONE, Vol. 9, Issue 12, pp. e114806, (2014) (PubMed).
: "Pivotal roles of lymphatic endothelial cell layers in the permeability to hydrophilic substances through collecting lymph vessel walls: effects of inflammatory cytokines." in: Lymphatic research and biology, Vol. 12, Issue 3, pp. 124-35, (2014) (PubMed).
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Development of full-thickness human skin equivalents with blood and lymph-like capillary networks by cell coating technology." in: Journal of biomedical materials research. Part A, (2015) (PubMed).
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- Target
- LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))
- Andere Bezeichnung
- Lyve-1 (LYVE1 Produkte)
- Synonyme
- LYVE1 antikoerper, XLKD1 antikoerper, CRSBP-1 antikoerper, HAR antikoerper, LYVE-1 antikoerper, 1200012G08Rik antikoerper, Crsbp-1 antikoerper, Lyve-1 antikoerper, Xlkd1 antikoerper, lymphatic vessel endothelial hyaluronic receptor 1a antikoerper, lymphatic vessel endothelial hyaluronan receptor 1 antikoerper, lyve1a antikoerper, LYVE1 antikoerper, Lyve1 antikoerper
- Hintergrund
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LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41 % similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Synonyms: LYVE1, HAR, XLKD1, LYVE-1, CRSBP-1 - NCBI Accession
- NP_006682, NM_006691
- UniProt
- Q9Y5Y7
- Pathways
- Glycosaminoglycan Metabolic Process
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