Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) Antikörper

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C)

Synonyme: BAFFR, CD268, BAFF-R, MGC138235, RGD1560810, TNFRSF13C

Klonalität: Monoklonal (11C1)

Wirt: Maus

Reaktivität: Human

Applikation: Durchflusszytometrie (FACS), Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN158960

Produktbeschreibung

Weitere Bezeichnung: CD268 (BAFF-R| BAFFR)

Immunogen: BAFF-R-L1.2 transfectants

Format: Purified

Isotyp: IgG1, kappa chain  (Passende Sekundärantikörper)

Klon: 11C1

Beschreibung: B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-kappa B activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-kappa B activation. Distribution: Mature B cells, B cell lymphoma, T cell subset Function: Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation Synonyms: TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor Structure: Type III transmembrane protein, TNF receptor superfamily, 19 kD

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is < 1.0 µg per 10 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Reinigung: The antibody was purified by affinity chromatography.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Lagerung: The antibody solution should be stored undiluted at 4°C.

Forschungsgebiet: CD Antigene

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Human peripheral blood lymphocytes stained with purified11C1, followed by anti-mouse IgG FITC

Publikationen

Publikationen: Thompson, Bixler, Qian et al.: "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF." in: Science (New York, N.Y.), Vol. 293, Issue 5537, pp. 2108-11, 2001 (PubMed).

Kayagaki, Yan, Seshasayee et al.: "BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2." in: Immunity, Vol. 17, Issue 4, pp. 515-24, 2002 (PubMed).

Ng, Sutherland, Newton et al.: "B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 2, pp. 807-17, 2004 (PubMed).

Ye, Wang, Wells et al.: "BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses." in: European journal of immunology, Vol. 34, Issue 10, pp. 2750-9, 2004 (PubMed).

Rodig, Shahsafaei, Li et al.: "BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders." in: Human pathology, Vol. 36, Issue 10, pp. 1113-9, 2005 (PubMed).