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Lamin A/C Antikörper (LMNA)

Details für Produkt anti-LMNA Antikörper Nr. ABIN1580429, Anbieter: Anmelden zum Anzeigen
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  • 2459
  • 74/76
  • CG6944
  • D5
  • DM[[O]]
  • Dm
  • Dm(0)
  • Dm0
  • Dm1
  • Dm2
  • DmLamin
  • DmO
  • Dm[[0]]
  • Dm[[1]]
  • Dm[[2]]
  • Dm[[mit]]
  • Dm[[o]]
  • Dmel\\CG6944
  • Dmo
  • LAM
  • Lam Dm[[0]]
  • Lam(Dm0)
  • LamDm[[0]]
  • LamDm[[o]]
  • Lam[[Dm0]]
  • Lamin Dm[[0]]
  • jf27
  • l(2)04643
  • l(2)25Ec
  • l(2)gdh-7
  • l(2)gdh7
  • l(2)jf27
  • lam
  • lamDm0
  • lamDm[[0]]
  • lamin
  • lamin Dm0
  • lamin Dm[[0]]
  • misg
  • nlam
  • cb948
  • fk66d12
  • wu:fk66d12
  • fpl
  • idc
  • lfp
  • cddc
  • emd2
  • fpld
  • hgps
  • ldp1
  • lmn1
  • lmnc
  • pro1
  • cdcd1
  • cmd1a
  • cmt2b1
  • lgmd1b
  • Lamin-A
  • Dhe
  • CDCD1
  • CDDC
  • CMD1A
  • CMT2B1
  • EMD2
  • FPL
  • FPLD
  • FPLD2
  • HGPS
  • IDC
  • LDP1
  • LFP
  • LGMD1B
  • LMN1
  • LMNC
  • LMNL1
  • PRO1
  • lmna-A
  • lamin-L(III)-like
Alternativen
anti-Maus Lamin A/C Antikörper für Western Blotting
Reaktivität
Human, Rind (Kuh), Schwein, Maus, Ratte (Rattus), Säugetier
294
146
130
30
25
14
11
10
8
5
4
4
3
2
1
1
1
1
1
1
Wirt
Maus
209
111
3
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser Lamin A/C Antikörper ist unkonjugiert
5
4
4
3
3
2
2
2
2
2
2
2
2
2
2
Applikation
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
275
109
100
77
63
58
33
32
32
24
11
2
2
2
2
2
2
1
Hersteller
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Bilder

Klon 4C4
Isotyp IgG1
Reinigung affinity purified antibody
Andere Bezeichnung Lamin A/C (LMNA Antibody Abstract)
Hintergrund Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm. Lamins function as skeletal components tightly associated with the inner nuclear membrane. Originally the proteins of the nuclear cytoskeleton were named Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that Lamins A and C were coded for by a single gene, while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74 kDa while Lamin C is 65 kDa. The Lamin A protein includes 98 amino acids missing from Lamin C, while Lamin C has a C-terminal 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other, as is the case with this monoclonal. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kinase 1 (CDK1), the key component of maturation promoting factor, the central regulator of cell division. Activity of this kinase increases during cell division and is responsible for the breakdown of the nuclear lamina. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lamina binding proteins. A truncated version of Lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging. The HGNC name for this protein is LMNA.
Forschungsgebiet Cytoskeleton, Extracellular Matrix
Pathways Apoptose, Caspase Kaskade in der Apoptose
Applikationshinweise The antibody solution can be used at dilutions of at least 1:1,000 in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:10,000 or lower.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store at 4°C short term or -20°C long term.
Bilder des Herstellers
Western Blotting (WB) image for anti-Lamin A/C Antikörper (LMNA) (ABIN1580429) Strip blots of crude HeLa cell extract stained with MCS-4C4. Note two strong clean ba...
Immunofluorescence (IF) image for anti-Lamin A/C Antikörper (LMNA) (ABIN1580429) HeLa cells staining with ABIN1580429 (red), and counterstained with ’s chicken polycl...
Allgemeine Veröffentlichungen Liu, Zhou: "Lamin A/C, laminopathies and premature ageing." in: Histology and histopathology, Vol. 23, Issue 6, pp. 747-63, 2008 (PubMed).

Fisher, Chaudhary, Blobel: "cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 17, pp. 6450-4, 1986 (PubMed).