CD36 Molecule (thrombospondin Receptor) (CD36) Antikörper (PE)

Antigen: CD36 Molecule (thrombospondin Receptor) (CD36)

Synonyme: FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3

Klonalität: Monoklonal (HM36)

Wirt: Hamster

Reaktivität: Maus

Konjugat: PE

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN155703

Produktbeschreibung

Weitere Bezeichnung: CD36

Isotyp: IgG

Klon: HM36

Beschreibung: CD36 is a 85 kD glycoprotein, also known as FAT, gpIIIb, or gpIV. It is a member of the class B scavenger receptor family, expressed on platelets, monocytes, macrophages, megakaryocytes, microvasculature, dendritic cells and mammary endothelial cells. The primary ligands for CD36 have been reported to be oxidized low density lipoprotein, anionic phospholipids, and collagens I, IV, and V. CD36 acts as a scavenger receptor thus promoting the removal of apoptotic neutrophils and other apoptotic bodies, as well as clearance of defective erythrocytes. Distribution: Platelets, monocytes, macrophages, microvascular and mammary endothelial cells Function: Scavenger receptor, recognition and phagocytosis of apoptotic neutrophils, adhesion Synonyms: FAT, gpIIIb, gpIV Structure: Scavenger receptor superfamily, 85 kD

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is < 0.25 µg per 10 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Reinigung: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Lagerung: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Forschungsgebiet: CD Antigene

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with HM36 PE

Publikationen

Publikationen: Greenwalt, Lipsky, Ockenhouse et al.: "Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine." in: Blood, Vol. 80, Issue 5, pp. 1105-15, 1992 (PubMed).

Endemann, Stanton, Madden et al.: "CD36 is a receptor for oxidized low density lipoprotein." in: The Journal of biological chemistry, Vol. 268, Issue 16, pp. 11811-6, 1993 (PubMed).

Hamilton, Thakur, Mayfair et al.: "MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34218-26, 2006 (PubMed).

Stuart, Bell, Stewart et al.: "CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex." in: The Journal of biological chemistry, Vol. 282, Issue 37, pp. 27392-401, 2007 (PubMed).