CD36 Molecule (thrombospondin Receptor) (CD36) Antikörper

Antigen: CD36 Molecule (thrombospondin Receptor) (CD36)

Synonyme: FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3

Klonalität: Monoklonal (HM36)

Wirt: Hamster

Reaktivität: Maus

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN155699

Produktbeschreibung

Weitere Bezeichnung: CD36

Format: Purified

Isotyp: IgG  (Passende Sekundärantikörper)

Klon: HM36

Beschreibung: CD36 is a 85 kD glycoprotein, also known as FAT, gpIIIb, or gpIV. It is a member of the class B scavenger receptor family, expressed on platelets, monocytes, macrophages, megakaryocytes, microvasculature, dendritic cells and mammary endothelial cells. The primary ligands for CD36 have been reported to be oxidized low density lipoprotein, anionic phospholipids, and collagens I, IV, and V. CD36 acts as a scavenger receptor thus promoting the removal of apoptotic neutrophils and other apoptotic bodies, as well as clearance of defective erythrocytes. Distribution: Platelets, monocytes, macrophages, microvascular and mammary endothelial cells Function: Scavenger receptor, recognition and phagocytosis of apoptotic neutrophils, adhesion Synonyms: FAT, gpIIIb, gpIV Structure: Scavenger receptor superfamily, 85 kD

Anwendungen

Applikationshinweise: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is < 0.5 µg per 10 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Reinigung: The antibody was purified by affinity chromatography.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Lagerung: The antibody solution should be stored undiluted at 4 °C.

Forschungsgebiet: CD Antigene

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with purified HM36, followed by anti-Armenian hamester IgG FITC

Publikationen

Publikationen: Greenwalt, Lipsky, Ockenhouse et al.: "Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine." in: Blood, Vol. 80, Issue 5, pp. 1105-15, 1992 (PubMed).

Endemann, Stanton, Madden et al.: "CD36 is a receptor for oxidized low density lipoprotein." in: The Journal of biological chemistry, Vol. 268, Issue 16, pp. 11811-6, 1993 (PubMed).

Hamilton, Thakur, Mayfair et al.: "MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34218-26, 2006 (PubMed).

Stuart, Bell, Stewart et al.: "CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex." in: The Journal of biological chemistry, Vol. 282, Issue 37, pp. 27392-401, 2007 (PubMed).