Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) Antikörper

Antigen: Actin, alpha 2, Smooth Muscle, Aorta (ACTA2)

Synonyme: AAT6, ACTSA, Actvs, a-SMA, SMalphaA, 0610041G09Rik, wu:fb63d03, MGC78870, ACTA2, actc1, actsa, MGC89192, MGC127800, ACT-4, DKFZp469E0314, Acta2, asma, acta, cftd, mpfd, nem1, nem2, nem3, acta2, cftd1, cftdm, MGC52636, MGC79039

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Huhn, Säugetiere

Applikation: Enzyme Immunoassay (EIA), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN153416

Produktbeschreibung

Weitere Bezeichnung: Aortic smooth muscle Actin / ACTA2

Gen-ID: 59, 25365

Immunogen: Synthetic peptide corresponding to N-terminus of human alpha smooth muscle isoformof actin.

Beschreibung: Actins are highly conserved proteins expressed in all eukaryotic cells. Actin filamentsform part of the cytoskeleton and play essential roles in regulating cell shape andmovement. Six distinct actin isotypes have been identified in mammalian cells. Each isencoded by a separated gene and is expressed in a developmentally regulated andtissue-specific manner, alpha and beta cytoplasmic actins are expressed in a widevariety of cells, whereas, expression of alpha skeletal, alpha cardiac, alpha vascular,and gamma enteric actins are more restricted to specialized muscle cell type. Smoothmuscle alpha actin is of further interest because it is one of a few genes whoseexpression is relatively restricted to vascular smooth muscle cells. Further more,expression of smooth muscle alpha actin is regulated by hormones, cell proliferation ,and altered by pathological conditions including oncogenic transformation andatherosclerosis. Alternate Names: anti-Smooth Muscle Actin antibody.

Spezifität: This antibody stains smooth muscle cells in vessel walls, gut wall, and myometrium.Myoepithelial cells in breast and salivary gland are also stained. It reacts with tumorsarising from smooth muscles and myoepithelial cells. Species Reactivity: Cross-reacts with Baboon, Chicken, Cow, Human, Mouse, Rabbit and Rat. Not yettested in other species. Localization: Cytoplasmic.

Synonyme: AAT6, ACTSA, Actvs, a-SMA, SMalphaA, 0610041G09Rik, wu:fb63d03, MGC78870, ACTA2, actc1, actsa, MGC89192, MGC127800, ACT-4, DKFZp469E0314, Acta2, asma, acta, cftd, mpfd, nem1, nem2, nem3, acta2, cftd1, cftdm, MGC52636, MGC79039

Anwendungen

Applikationshinweise: Suggested working dilutions: ELISA 0.1 - 1.0 ug/ml,Western Blot 0.5 - 2.0 ug/ml,Immunohistochemistry-Paraffin 1/100-1/400

Konzentration: 0.2 mg/ml

Buffer: PBS [pH 7.4]. Preservative: 0.09% sodium azide.

Lagerung: Store at 4 degrees C. Do not freeze.

Forschungsgebiet: Extrazelluläre Matrix, Zell-/Gewebemarker

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Formalin-fixed, paraffin-embedded Human Leiomyoma stained with ABIN153416

Publikationen

Publikationen: Jeyasuria, Wetzel, Bradley et al.: "Progesterone-regulated caspase 3 action in the mouse may play a role in uterine quiescence during pregnancy through fragmentation of uterine myocyte contractile proteins." in: Biology of reproduction, Vol. 80, Issue 5, pp. 928-34, 2009 (PubMed).