MTOR Antikörper (Mechanistic Target of Rapamycin (serine/threonine Kinase)) (AA 2412-2461)

Details for Product anti-FRAP1 Antibody No. ABIN1531715, Anbieter: Anmelden zum Anzeigen
Antigen
  • FRAP1
  • FRAP
  • FRAP2
  • RAFT1
  • RAPT1
  • 2610315D21Rik
  • AI327068
  • Frap1
  • flat
  • frap1
  • tor
  • wu:fc22h08
  • mechanistic target of rapamycin (serine/threonine kinase)
  • MTOR
  • Mtor
  • mtor
Epitop
AA 2412-2461, pThr2446
66
36
27
23
21
15
15
13
12
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4
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2
2
2
2
2
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2
1
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Reaktivität
Human, Maus, Ratte (Rattus)
378
200
197
18
9
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7
7
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4
2
2
2
1
1
Wirt
Kaninchen
324
49
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Klonalität
Polyklonal
Konjugat
Dieser MTOR Antikörper ist unkonjugiert
8
8
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Applikation
ELISA, Western Blotting (WB)
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22
8
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7
3
2
2
2
2
1
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Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The antiserum was produced against synthesized peptide derived from human mTOR around the phosphorylation site of Thr2446.
Isotyp IgG
Spezifität

mTOR (Phospho-Thr2446) Antibody detects endogenous levels of mTOR only when phosphorylated at Thr2446.

PhosphorylationH:T2446 M:T2446 R:T2446

Reinigung The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
Reinheit > 95 %
Andere Bezeichnung mTOR (FRAP1 Antibody Abstract)
Hintergrund

Synonyms: FRAP, FRAP1, FRAP2, RAFT1, Rapamycin target protein, kinase mTOR

NCBI Gene Symbol: MTOR

Molekulargewicht 288 kDa
Gen-ID 2475
OMIM 601231
UniProt P42345
Forschungsgebiet Cardiovascular, Cardiogenesis, Cell Cycle, DNA/RNA
Pathways PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagie, CXCR4-mediated Signaling Events
Applikationshinweise WB: 1:500~1:1000 ELISA: 1:10000
Kommentare

Unigene-Number: Hs.338207 (NCBI Gene Symbol: MTOR)

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Stable at -20°C for at least 1 year.
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (pThr2446), (AA 2412-2461) antibody (ABIN1531715) Western blot analysis of extracts from NIH-3T3 cells treated with Insulin 0.01U/ml 15...
Allgemeine Veröffentlichungen Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Onyango, Lubyova, Gardellin, Kurzbauer, Weith: "Molecular cloning and expression analysis of five novel genes in chromosome 1p36." in: Genomics, Vol. 50, Issue 2, pp. 187-98, 1998 (PubMed).

Brown, Albers, Shin, Ichikawa, Keith, Lane, Schreiber: "A mammalian protein targeted by G1-arresting rapamycin-receptor complex." in: Nature, Vol. 369, Issue 6483, pp. 756-8, 1994 (PubMed).

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