MTOR Antikörper (Mechanistic Target of Rapamycin (serine/threonine Kinase)) (pThr2446)

Details for Product anti-FRAP1 Antibody No. ABIN1531715, Anbieter: Anmelden zum Anzeigen
Antigen
  • FRAP1
  • FRAP
  • FRAP2
  • RAFT1
  • RAPT1
  • 2610315D21Rik
  • AI327068
  • Frap1
  • flat
  • frap1
  • tor
  • wu:fc22h08
  • mechanistic target of rapamycin (serine/threonine kinase)
  • MTOR
  • Mtor
  • mtor
Alternativen
anti-Human MTOR Antikörper für Immunofluorescence (fixed cells)
Epitop
pThr2446
64
27
26
22
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20
15
15
12
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2
2
2
2
2
1
1
1
1
1
1
1
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1
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1
Reaktivität
Human, Maus, Ratte (Rattus)
368
200
198
18
9
8
7
7
7
7
4
2
2
2
1
1
Wirt
Kaninchen
316
48
3
1
Klonalität
Polyklonal
Konjugat
Dieser MTOR Antikörper ist unkonjugiert
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8
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5
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4
4
4
4
4
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4
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4
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3
Applikation
ELISA, Western Blotting (WB)
246
111
93
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55
52
37
20
7
7
7
6
3
2
2
2
1
1
1
Optionen
Hersteller
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Immunogen The antiserum was produced against synthesized peptide derived from human mTOR around the phosphorylation site of Thr2446.
Isotyp IgG
Spezifität MTOR (Phospho-Thr2446) Antibody detects endogenous levels of mTOR only when phosphorylated at Thr2446.
Reinigung The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation.
Reinheit > 95 %
Andere Bezeichnung mTOR (FRAP1 Antibody Abstract)
Hintergrund Molecular weight of target protein: 288 kDa
Synonyms: FRAP, FRAP1, FRAP2, RAFT1, Rapamycin target protein, kinase mTOR
Molekulargewicht 288 kDa
Gen-ID 2475
OMIM 601231
UniProt P42345
Forschungsgebiet Cardiovascular, Cardiogenesis, Cell Cycle, DNA/RNA
Pathways PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagie, CXCR4-mediated Signaling Events
Applikationshinweise WB: 1:500-1:1000
ELISA: 1:10000
Optimal working dilution should be determined by the investigator.
Kommentare

Unigene-Number: Hs.338207 (NCBI Gene Symbol: MTOR)

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 52 % glycerol.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Stable at -20 °C for at least 1 year.
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-MTOR Antikörper (Mechanistic Target of Rapamycin (serine/threonine Kinase)) (pThr2446) (ABIN1531715) Western blot analysis of extracts from NIH-3T3 cells treated with Insulin 0.01U/ml 15...
Allgemeine Veröffentlichungen Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Onyango, Lubyova, Gardellin, Kurzbauer, Weith: "Molecular cloning and expression analysis of five novel genes in chromosome 1p36." in: Genomics, Vol. 50, Issue 2, pp. 187-98, 1998 (PubMed).

Brown, Albers, Shin, Ichikawa, Keith, Lane, Schreiber: "A mammalian protein targeted by G1-arresting rapamycin-receptor complex." in: Nature, Vol. 369, Issue 6483, pp. 756-8, 1994 (PubMed).