Chemokine (C-X-C Motif) Receptor 2 (CXCR2) Antikörper

Antigen: Chemokine (C-X-C Motif) Receptor 2 (CXCR2)

Synonyme: CD182, CXCR2, IL8R2, IL8RA, CMKAR2, CDw128b, CD128, Il8rb, CDw128, Cmkar2, Gpcr16, IL-8Rh, IL-8rb, mIL-8RH, Cxcr2, IL8RB

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunpräzipitation (IP), Western Blot (WB)

Produktnummer: ABIN152847

Produktbeschreibung

Weitere Bezeichnung: CD182 / IL8RB

Gen-ID: 3579, 29385

Immunogen: Synthetic peptide (selective for CXCR2 receptor +C-terminal region).

Beschreibung: Chemokine (Chemoattractant Cytokines) are small peptides that are potent activatorsand chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells.Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors(GPCR), which regulate the trafficking and activation of leukocytes, and operate asco-receptors in the entry of HIV-1 and proliferation and migration of immature neurons,glia and their precursors. Furthermore, chemokine receptors participate in the etiologyand progression of various brain disorders, including AIDS dementia,neuro-inflammatory disease and neuroplasia, making them important potentialtherapeutic targets in these cases several subtypes of CXCR have been characterized. Activation of na.

Spezifität: ABIN152847 detects CXCR2 expressed on intestinal microvascular cells. Species Reactivity: Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. Localization: Integral membrane protein.

Anwendungen

Applikationshinweise: Suggested working dilutions: immunoprecipitation 1:250,Western Blot 1:500,Immunohistochemistry-Frozen

Konzentration: 0.6 mg/ml

Buffer: Stabilization buffer. Preservative: 0.02% sodium azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Forschungsgebiet: CD Antigene, Oberflächenrezeptoren der Immunzellen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western Blot of Chemokine Receptor with ABIN152847. Antibody dilution (1:500 in DilObuffer). MWM on right.

Publikationen

Publikationen: Onan, Allan, Quinn et al.: "The chemokine Cxcl1 is a novel target gene of parathyroid hormone (PTH)/PTH-related protein in committed osteoblasts." in: Endocrinology, Vol. 150, Issue 5, pp. 2244-53, 2009 (PubMed).