Angiostatin (ANG) Antikörper

Antigen: Angiostatin (ANG)

Synonyme: DKFZp779M0222, Pg, AI649309, Ab1-346, PLG, LPA, wu:fb70e09, plg, DKFZp470G2422

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN152703

Produktbeschreibung

Weitere Bezeichnung: Angiostatin

Gen-ID: 5340, 18815, 85253

Immunogen: Synthetic Peptide: V(1)YLSECKTGIGNGYRGTMS(19).Immunizing peptide correspondsto amino acid residues 1-19 from mouse angiostatin. This sequence is 95% and 84%conserved in rat and human angiostatin, respectively.

Beschreibung: Angiostatin is a proteolytic fragment that comprises the first four kringle domains of the~85 kDa plasminogen. Angiostatin reduces endothelial cell proliferation and acts as anpotent inhibitor of angiogenesis and tumor growth. Alternate Names: Anti-Angiostatin antibody, anti- Microplasmin antibody.

Spezifität: Detects recombinant human angiostatin. Species Reactivity: Cross-reacts with Human.Expected to cross-react with Rat and Mouse due to sequencehomology.Not yet tested in other species.

Anwendungen

Applikationshinweise: Western Blot: use at a concentration of 2 ug/ml Optimaldilutions / concentrations should be determined by the end user.By Western blot, thisantibody detects a 50 kDa protein representing recombinant human angiostatin.

Konzentration: 1 mg/ml

Buffer: PBS, 1 mg/ml BSA. Preservative: 0.05% Sodium azide.

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Forschungsgebiet: Krebs, Angiogenese, Zytokine

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Drixler, Voest, van Vroonhoven et al.: "Angiogenesis and surgery: from mice to man." in: The European journal of surgery = Acta chirurgica, Vol. 166, Issue 6, pp. 435-46, 2000 (PubMed).

Sim, MacDonald, Gubish: "Angiostatin and endostatin: endogenous inhibitors of tumor growth." in: Cancer metastasis reviews, Vol. 19, Issue 1-2, pp. 181-90, 2001 (PubMed).

Agarwal, Muunoz-Nuajar, Klueh et al.: "N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer." in: The American journal of pathology, Vol. 164, Issue 5, pp. 1683-96, 2004 (PubMed).

Nocito, Dahm, Jochum et al.: "Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts." in: Cancer research, Vol. 68, Issue 13, pp. 5152-8, 2008 (PubMed).