ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) Antikörper

Antigen: ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1)

Synonyme: MGC3285, MGC51750, Atpa-1, BC010319, MGC38419, Nkaa1b, atp1a1, atp1a1a.1, ATP1A1

Klonalität: Monoklonal (464-6)

Wirt: Maus

Reaktivität: Hund, Human, Affe, Maus, Schwein, Kaninchen, Ratte (Rattus), Schaf, Xenopus laevis

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunfluoreszenz (IF), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN152492

Produktbeschreibung

Weitere Bezeichnung: ATP1A1

Gen-ID: 476, 25650

Immunogen: Purified Na,K-ATPase from rabbit renal outer medulla.

Format: Ascites

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 464-6

Beschreibung: Sodium Potassium ATPase is an integral membrane protein complex that hydrolyzesATP to maintain the transmembrane gradients of Na+ and K+ found in most mammaliancells. The enzyme is comprised of an alpha and beta subunit. The alpha-polypeptidehas been shown to be the catalytically active subunit, wherease the Beta-polypeptideappears to be necessary for the assembly and transport of the sodium pump to theplasma membrane.Sodium Potassium ATPase alpha-1 subunit, in brain, is expressed in both neuronal andnon-neuronal cells. Alternate Names: anti-ATP1A1 antibody, anti-Na+/K+ ATPase 1 antibody, anti-Sodium pump 1 antibody,anti-ATPase Na+/K+ transporting alpha 1 polypeptide antibody, anti-Na+/K+ ATPasealpha-1 subunit antibody, anti-Na+, K+ ATPase alpha subunit antibody, anti-alpha 1sodium potassium ATPase antibody, anti-sodium potassium ATPase alpha A catalyticpolypeptide antibody, anti-sodium pump subunit alpha-1 antibody, anti-MGC3285antibody, anti-MGC51750 antibody, anti-ATPase alpha 1 (Na/K) antibody.

Spezifität: This antibody is specific for Na,K-ATPase alpha 1 subunit. Species Reactivity: Human, porcine, monkey, murine, rabbit, canine, sheep, rat, and Xenopus.

Anwendungen

Applikationshinweise: Suggested working dilutions: immunohistochemistry 1:200,immunofluorescence 1:100-1:1000,Western Blot 1:1000-1:10000,Immunohistochemistry-Paraffin 1:200

Konzentration: 2 mg/ml

Buffer: Ascitic fluid. Preservative: 0.1% sodium azide.

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western Blot analysis detecting Na, K-ATPase (alpha) in porcine proximal tubule protein, using ABIN152492.

Staining of enodmetrial glands within the uterus using ABIN152492. Note the absence of staining in the surrounding myometrial smooth muscle.

Publikationen

Publikationen: Xavier, Piek, Fujii et al.: "Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone." in: The Journal of biological chemistry, Vol. 279, Issue 15, pp. 15167-76, 2004 (PubMed).

Knox, Belous, Pierce et al.: "Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 287, Issue 3, pp. G533-40, 2004 (PubMed).

Holzer, Katano, Klomp et al.: "Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 19, pp. 6744-9, 2004 (PubMed).

Pohl, Ring, Korkmaz et al.: "FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts." in: Molecular biology of the cell, Vol. 16, Issue 1, pp. 24-31, 2004 (PubMed).

Mukhopadhyay, Shah, Patel et al.: "Monocrotaline pyrrole-induced megalocytosis of lung and breast epithelial cells: Disruption of plasma membrane and Golgi dynamics and an enhanced unfolded protein response." in: Toxicology and applied pharmacology, Vol. 211, Issue 3, pp. 209-20, 2006 (PubMed).

Tarn, Skorobogatko, Taguchi et al.: "Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms." in: Cancer research, Vol. 66, Issue 10, pp. 5477-86, 2006 (PubMed).

Pessach, Shmelzer, Leto et al.: "The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase" in: Journal of leukocyte biology, Vol. 80, Issue 3, pp. 630-9, 2006 (PubMed).

Perry, Dembla-Rajpal, Hall et al.: "A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport." in: The Journal of biological chemistry, Vol. 281, Issue 49, pp. 38071-9, 2006 (PubMed).

Tansley, Burgess, Bryan et al.: "The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein." in: Journal of lipid research, Vol. 48, Issue 5, pp. 1022-34, 2007 (PubMed).

Qu, Perdomo, Su et al.: "Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice." in: Journal of lipid research, Vol. 48, Issue 7, pp. 1476-87, 2007 (PubMed).

Jahn, Leifheit, Gooch et al.: "Lipid rafts are required for Kit survival and proliferation signals." in: Blood, Vol. 110, Issue 6, pp. 1739-47, 2007 (PubMed).

Padilla, Cottrell, Roosterman et al.: "Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins." in: The Journal of cell biology, Vol. 179, Issue 5, pp. 981-97, 2007 (PubMed).

Kadereit, Kumar, Wang et al.: "Evolutionarily conserved gene family important for fat storage." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 94-9, 2008 (PubMed).

Winterstein, Trotter, Kraemer-Albers: "Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling." in: Journal of cell science, Vol. 121, Issue Pt 6, pp. 834-42, 2008 (PubMed).

Burgess, Parkinson, Racke et al.: "ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo." in: Journal of lipid research, Vol. 49, Issue 6, pp. 1254-67, 2008 (PubMed).

Peyrottes, Navarro, Ondo-Mendez et al.: "Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 160, Issue 2, pp. 215-25, 2009 (PubMed).