APEX1 / REF-1 (2 set) Antikörper

Antigen: APEX1 / REF-1 (2 set)

Klonalität: Monoklonal (Var-)

Wirt: Bitte anfragen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Chromatin-Immunopräzipitation (ChiP), Immunfluoreszenz (IF), Immunpräzipitation (IP), Western Blot (WB)

Produktnummer: ABIN152196

Produktbeschreibung

Klon: Var-

Beschreibung: We know how important it is to your research to have access to antibodies specific foryour model. As it is often impossible to know which antibody will work best for a specificsample and application, we now offer SuperNovus Packs. These packs include differentantibodies to the same protein to give you the ability to decide for yourself. TheSuperNovus Packs are all offered at a discount price compared to purchasing eachantibody individually.The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for therepair of AP sites in DNA. In addition, this enzyme functions as a redox factor facilitatingthe DNA binding capability of FOS, JUN, NfkB, HIF-1 alpha, Pax-5, Pax-8 and othertranscription factors. APE/ref-1 has also been shown to control p53 activity throughredox alteration. APE is linked to apoptosis, associated with thioredoxin, and alteredlevels of APE/ref-1 have been found in some cancers. APE appears to form a uniquelink between the DNA base excision pathway, oxidative signaling, transcriptionregulation, cancer and cell-cycle control.

Spezifität: Species Reactivity: See individual datasheets.

Anwendungen

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Immunohistochemical staining of APE-ref-1 in prostate cancer, using ABIN151028

Western analysis of APE-ref-1 in HeLa and 3T3 cell lysates, using ABIN151028

Publikationen

Publikationen: Evans, Limp-Foster, Kelley: "Going APE over ref-1." in: Mutation research, Vol. 461, Issue 2, pp. 83-108, 2001 (PubMed).

Zou, Luo, Reed et al.: "Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain." in: Blood, Vol. 109, Issue 5, pp. 1917-22, 2007 (PubMed).

Briegert, Kaina: "Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents." in: Cancer research, Vol. 67, Issue 1, pp. 26-31, 2007 (PubMed).